Avestin EmulsiFlex-C5 User Manual

www.avestin.com
AVESTIN, Inc.
2450 Don Reid Drive, Ottawa, ON, Canada, K1H 1E1, e-mail:avestin@avestin.com, website:www.avestin.com
Tel: -613-736-0019, Fax: -613-736-8086, US & CDN customers call toll free: 1-888-AVESTIN (283-7846)
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Operating Instructions for the EmulsiFlex

-C5
High Pressure Homogenizer
EmulsiFlex Principle of Operation:
A high pressure pump (C) pushes the product
through an adjustable homogenizing valve (D).
The product can also be passed through a
membrane (E). It can be collected (G) or
recycled to the reservoir (A) via tubing/pipes
or heat exchanger (F).
EmulsiFlex equipment can be delivered as:
1-High pressure homogenizer (A,C,D,F,G)
2-High pressure filter/extruder (A,C,E,G)
3-Homogenizer/filter/extruder combination
(A,C,D,E,G)
4-Two-phase homogenizer/filter/extruder with precision
metering pumps, or as shown to the left (A,B,C,D,E,F,G).
B
JACKETED
CONTAINER
D
AG
E
F
C

Avestin EmulsiFlex-C5 Specifications

General

Type	High-Pressure Homogenizer
Flow Rate	Up to 5 L/h
Motor Power	1.5 kW
Particle Size Reduction	Down to 100 nm
Max Pressure	1500 bar
Maximum Pressure	1500 bar
Material	Stainless steel
Temperature control	Optional
Applications	Cell Disruption

Summary

1. Warnings and General Information

General Safety and Operational Guidelines

Covers essential safety precautions, proper operation, and instrument care for safe use.

2. Requirements for Operation

Compressed Air/Gas and Cooling Fluid

Details required air/gas pressure, source, and cooling fluid options for instrument function.

3. Operating Instructions

3.1 How to Run the Pump

Step-by-step guide for connecting air supply and starting the pump motor for processing.

3.2 How to Operate the Filter/Extruder

4. Specific Applications

Cell Rupture, Liposomes, Emulsions, and Dispersions

5. Protocol to Clean and Sterilize

Cleaning Procedures

Sterilization Methods: Steam and Autoclave

6. Troubleshooting

Common Operational Issues and Solutions

Addresses pump stalling, leaks, priming issues, and product bubbles with corrective actions.

7. Plunger Seal Replacement

Seal Removal and Insertion Procedures