Endress+Hauser Liquisys M CLM223/253 - Page 54

Commissioning Liquisys M CLM223/253
54 Endress+Hauser
Limit values for pharmaceutical water according to United States Pharmacopeia (USP)
and European Pharmacopoeia (EP) (conductive only)
The transmitter (conductive sensors only) can monitor "Water for Injection" (WFI), "Highly
Purified Water" (HPW) and "Purified Water" (PW) according to the standard United States
Pharmacopeia (USP) part 645 and European Pharmacopoeia (EP).
USP function: For "Water for Injection" (WFI) according to the standard of USP and EP and
for "Highly Purified Water" (HPW) according to the standard of EP the transmitter uses the
temperature depending limit values of the following table:
The measurement is performed as follows:
• The transmitter determines the uncompensated conductivity and the water temperature.
• The transmitter rounds off the temperature to the next smaller 5 °C step and compares the
actual measured conductivity with the value of the table.
• If the measured value exceeds the table value an alarm (E151) will be triggered.
a0006793
Fig. 34: Sequence of a cleaning cycle
A
B
C
0
1
Hold
Water
Cleaner
Contact on
Contact off
t
0
t
1
t
2
-t
1
t
3
-t
2
t
4
-t
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t
5
-t
4
Normal mode
Cleaning start
Pre-rinse time
Cleaning time
Post rinse time
Hold dwell period
Temperature [°C/°F] Conductivity [μS/cm] Temperature [°C/°F] Conductivity [μS/cm]
0/32 0.6 55/131 2.1
5/41 0.8 60/140 2.2
10/50 0.9 65/149 2.4
15/59 1.0 70/158 2.5
20/68 1.1 75/167 2.7
25/77 1.3 80/176 2.7
30/86 1.4 85/185 2.7
35/95 1.5 90/194 2.7
40/104 1.7 95/203 2.9
45/113 1.8 100/212 3.1
50/122 1.9
A
B
C
t
0
t
1
t
2
t
3
t
4
t
5
0
0
0
1
1
1