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ESA Corona CAD User Manual
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Corona
®
CAD
®
Detector
Corona
®Plus
CAD
®
Detector
Operating & Maintenance Manual
ESA Biosciences, Inc.
22 Alpha Road
Chelmsford, MA 01824-4171 U.S.A.
Telephone: (978) 250-7000
Fax: (978) 250-7090
www.
esainc.com
P/N 70-6258
Rev. G
2
Table of Contents
Safety/Operating Symbols
5
Warnings and Safety Precautions
6
Important Operating Considerations
10
Do's and Don'ts
13
Table of Contents
15
Chapter 1: Introduction
21
Overview of the Corona CAD Detectors
21
Features of the Corona and Corona Plus Detectors
22
Overview of this Manual
22
The Detector Module Includes
23
Corona Detector Organizer Modules
24
Nitrogen Generator
24
Component Location
25
Mode of Operation of the Detector
28
Additional Information
30
Support from ESA
31
Frequently Asked Questions
32
Chapter 2 Installation
35
Introduction
35
Environmental Conditions
35
Physical Location of the Corona Detector
35
Power Requirements
37
Space Requirements
38
Nebulization Gas
39
Unpacking the Detector
39
Installing the Detector
40
Basic Installation
40
Locating the Detector
40
Power Source
41
Gas Source
42
Exhaust
43
Drain and Vent Installation
43
HPLC System
47
USB Connections
49
Other Connections
49
Setting up Corona Plus Nebulizer Heater
49
Test Protocol
50
Role of the Test Protocol
50
Setup
50
Protocol
51
ESA Biosciences Corona CAD Detector Test Worksheet
54
General Operations
55
Turning off the Corona Detector
55
Emptying the Waste Bottle
55
Storing the Corona Detector
56
Other Detector Configurations
56
Using the Corona in Parallel with Another Detector
56
Setting up the Thermal Organizer
57
Making Electrical Connections
58
Description of the Rear Panel of the Detector
58
Interfacing to the ESA Model 584 Solvent Delivery Module
61
Interfacing to Other Solvent Delivery Modules
62
Mobile Phase Formulation
63
Supplies
63
Procedure
63
Mobile Phase Preparation
63
Degassing Mobile Phase
64
Wrap up
66
Mobile Phase Qualification
66
Column Conditioning Procedure
67
Supplies
67
Procedure
67
Chapter 3: The Corona Cad Firmware
69
Introduction
69
Initialization of the Detector
70
The Keypad
72
Creating/Editing a Corona CAD Detector Method
73
Overview
73
Edit the Method Select Screen
73
Edit the Security Screen
74
Edit the Parameters Screen
75
Creating/Editing a CAD + TL Method
76
Timeline Screen
76
End Event Screen
78
Set Contact Screen
78
Autozero Screen
79
Filter Screen
79
Marker Screen
79
Range Screen
80
Gas Screen
80
Hold Screen
80
Loop Screen
81
Reset Screen
81
Save Method Screen
81
Method # Zero
82
Using a Method to Collect Data
83
The System Screens
86
Role of the System Screens
86
RS232 Setup Screen
86
Deleting Methods Screen
87
Event Marks Screen
88
Date & Time Setup Screen
89
Remote Screen
89
Inputs Screen
90
Contacts Screen
91
Thermal Organizer Setup Screen
92
Self Test Screen
93
Nebulizer Heater Setup Screen
93
How to Create a Timeline Method
95
Chapter 4: Using the Detector in a Hplc System
97
Introduction
97
Operating the Corona Detector
97
Turning on the Detector
97
Maintaining the Detector between Analyses
99
Shutting down the Detector
99
Mobile Phase Considerations
100
Column Considerations
100
Sample Considerations
101
Maximizing the Performance of the Assay
102
Overview
102
Selection of the Proper Output Range
102
Setting the Filter
102
An Experiment to Ensure that the Chromatograph and the Detector Are Functioning Properly
103
Analysis of Data
105
Effects of Gradient Elution on Response
107
Chapter 5 Maintenance and Troubleshooting
109
Introduction
109
Detector Maintenance
110
Overview
110
Daily Maintenance
111
Weekly Maintenance
111
Monthly Maintenance
112
Quarterly Maintenance
112
Additional Periodic Maintenance
112
Nitrogen Generator
113
Customer Service of the Detector
113
In-Line Filter Elements
113
Frequency of Changing Filter Elements
113
Checking the Pressure Drop Across the Filter
114
Changing a Filter
114
Changing the Line Fuses
115
Replacing the Gas Filters
116
Cleaning the Detector
117
Cleaning the Corona Detector Unit
117
Cleaning the Corona Detector Organizer and Thermal Organizer
117
Establishing a System Log
118
General Troubleshooting Approach
118
Detector Related Issues
120
Internal Electronic Diagnostic Programs
120
Gas
122
Drainage
123
Gain Range
124
Grounding Issues
125
HPLC Related Issues
126
Pump Noise
126
Mobile Phase Flow
127
Column
128
Mobile Phase
129
Standard and Sample Related Issues
130
Thermal Organizer Issues
131
Noise Review
132
General Troubleshooting Guidelines
133
Erratic/Noisy Baseline
135
High Background Currents
136
Increase in Back Pressure
137
Loss of Response
138
Inability to Autozero the Signal
139
Detector Test Procedure
139
Power Supply Board and Logic Board Replacement
140
Replacing the Power Supply Board
140
Replacing the Logic Board
140
Appendix A: Corona and Corona Plus Detector Specifications
141
General Operating Specifications
141
A.2 Timeline Specifications
142
External Requirements
142
Physical Specifications
142
Timeline Specifications
142
A.5 Environmental
143
Certifications
143
Environmental
143
Appendix Brecommended Supplies and Spare Parts
145
B.1 Corona Accesories
145
Cables
145
Corona Accesories
145
Corona Replacement Parts
145
B.4 Manuals
146
Fuses
146
Manuals
146
Nitrogen Gas Supply
146
Organizer Module Spare Parts
146
Test Standards and Guard Column
146
Thermal Organizer Module Spare Parts
146
Appendix C: Organizer and Thermal Organizer
147
C.1 Overview
147
Overview
147
Unpacking the Organizer
147
Installing the Corona Organizer Module
149
General Information
149
Removing the Organizer Chassis Plate
151
Installing the Pulse Damper
151
Installing a Rheodyne Manual Sample Injector Valve
152
Installing the In-Line Filter
153
Installing the Column Holder
153
Manual Sample Injector Overflow Line Bracket
154
Final Assembly
155
Installing the Corona Thermal Organizer Module
156
General Information
156
Installing the Pulse Damper
157
Removing the Organizer Chassis Plate
157
Installing a Rheodyne Manual Sample Injector Valve
158
Installing the Column Holder
159
Installing the In-Line Filter
159
Installing the Temperature Probe
159
Final Assembly
161
Manual Sample Injector Overflow Line Bracket
161
C.5 Troubleshooting
163
Cleaning
164
Maintenance on a Daily Basis
164
Maintenance on a Monthly Basis
164
Maintenance and Cleaning
163
Troubleshooting
163
Appendix D: Firmware Flow Chart
165
Appendix Edrain/Vent Assembly - Old Styles
167
Installing the Drain/Vent Assembly
168
Installing the Drain/Vent Assembly
173
Glossary
177
Index
187
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ESA Corona CAD Specifications
General
Field of View
90°
Communication Interface
Wired
Coverage
15 m
Detection Range
15m
Current Consumption
25mA (typical)
Technology
Microwave + Passive Infrared (PIR)