MATERIAL SAFETY DATA SHEET
MSDS Number:
00057
Effective Date:
04/20/2001
Product Name: FM-200 Page:
5 of 7
SECTION X - STABILITY AND REACTIVITY
Additional Information
No information available
SECTION XI - TOXICOLOGICAL INFORMATION
VALUE (LD50 OR LC50) ANIMAL ROUTES COMPONENTS
>788,696 ppm/4H Rat Acute Inhalation 1,1,1,2,3,3,3-Heptafluoropropane
Toxicological Information:
The human health hazards of this product are expected to be similar to other liquefied gases including N2,
CO2, CFCs, HCFCs, and HBFCs. Therefore, direct eye or skin contact with the liquid or cold gas can cause
chilling or possibly frostbite of exposed tissues. Inhalation of high concentrations can be harmful or fatal
due to oxygen deprivation and/or heart irregularities (arrhythmias). Misuse of the product by deliberately
inhaling high concentrations of this gas could cause death without warning. Persons with preexisting
cardiac or central nervous system disorders may be more susceptible to effects of an overexposure.
When tested with and without metabolic activation over a concentration range of 43.9-93.5%,
heptafluoropropane was not mutagenic in S. typhimurium. Neither toxicity nor mutagenicity was observed
in a mouse lymphoma assay when heptafluoropropane was tested to a concentration of 56.8%. Neither
toxicity nor an increase in micronuclei was observed in mice exposed to 10.5% heptafluoropropane.
Therefore, there is no evidence that heptafluoropropane is capable of inducing gene or chromosomal
mutations in vitro or chromosomal effects in vivo. In other studies, heptafluoropropane did not show
genotoxicity or cytotoxicity.
Animal studies have found the rat 4 hour LC50 to be >788,696 ppm (~80%), the highest level tested. A
cardiac sensitization study in dogs found the No Observable Adverse Effect Level (NOAEL) to be 9.0%. The
Lowest Observable Adverse Effect Level (LOAEL) for this study was reported to be 10.5%. A 90 day
inhalation study did not find any exposure related effects at 105,000 ppm (10.5% vol./vol.), the highest level
tested. Inhalation studies looking for developmental effects on pregnant rabbits and rats or their offspring
did not show any exposure related effects at the highest concentrations tested (105,000 ppm).
Additional Information
No information available
SECTION XII - ECOLOGICAL INFORMATION
Ecological Information: No information available
Additional Information
No information available
SECTION XIII - DISPOSAL CONSIDERATIONS
Disposal Considerations: Non-contaminated product is reclaimable. Contact Great Lakes
Chemical Corporation for information. Otherwise, dispose of waste in
an approved chemical incinerator equipped with a scrubber as allowed
by current Local, State/Province, Federal/Canadian laws and
regulations.
Additional Information
No information available
To Next Page
Loading...