PermkinElmer NexION 300 ICP-MS User Manual

Introduction
PerkinElmer
®
ICP-MS instruments are complete systems
with the exception of the following items which must
be provided by the customer: electrical power, exhaust
vents, argon gas supplies with approved regulator, cell
gas supply, and coolant system.
Required Environmental Conditions
The laboratory environment in which the NexION
®
300
ICP-MS instrument is installed should meet the following
conditions:
• Theroomtemperatureshouldbebetween15and
30˚C(59-86˚F)withamaximumrateofchangeof
3˚C(5˚F)perhour.
• Therelativehumidityshouldbebetween20and
80%,non-condensing.Foroptimumperformance,
the room temperature should be controlled at
20±2˚C(68±3.6˚F),andtherelativehumidity
shouldbebetween35and50%.
• Theinstrumentiscertifiedforoperationatelevationsup
to2000meters(6562ft.)abovesealevel.
In addition, the instrument should be located in an
area that is:
- Indoors
-Freeofsmoke,dustandcorrosivefumes
- Not prone to excessive vibration
- Out of direct sunlight
- Away from heat radiators
In order to minimize contamination problems, a
dust-freeenvironmentisnecessary.Forultra-trace
techniques, environmental contamination becomes a
limiting factor in the analysis. To quantitate ubiquitous
elementssuchasFe,Ca,K,Na,etc.below1ppb(µg/L),
aclass1000environmentisnecessaryforsample
preparation and analysis. This is not an indication of
the performance limitations of the instrument, but
a recommendation for an ultra-clean environment.
The NexION 300 ICP-MS can be installed into a mobile
laboratory if vibration is isolated.
PREPARING YOUR LAB
ICP-Mass Spectrometry
Preparation Checklist
• Environmentalconditions
• Electricalrequirements
• Spacerequirements
• Exhaustventilation
• Coolantrequirements
• Argongasrequirements
• Cellgasrequirements
NexION300ICP-MS

PermkinElmer NexION 300 ICP-MS Specifications

General

Type	Inductively Coupled Plasma Mass Spectrometer (ICP-MS)
Manufacturer	PerkinElmer
Model	NexION 300
Detection Limit	ppt levels
Plasma Source	Argon plasma
Mass Analyzer	Quadrupole Mass Analyzer
Nebulizer	Concentric glass nebulizer
Spray Chamber	Cyonic spray chamber
Interface	Cones (sampler and skimmer)
Nebulizer Gas Flow	0.8-1.2 L/min
Gas flow control	Mass flow controllers
Quadrupoles	Three quadrupoles (Q1, Q2, Q3)
Dynamic Range	9 orders of magnitude
Software	Syngistix
RF Generator Frequency	40.68 MHz

Summary

Introduction

Required Environmental Conditions

General Laboratory Requirements

Laboratory Hygiene

Guidelines for maintaining a clean work area to prevent sample contamination and ensure a safe working environment.

Working with Chemicals

Safety protocols for handling, storing, and disposing of hazardous chemicals used with the instrument.

Location and Space Requirements

Space Requirements

Details on instrument placement, clearance, and workstation layout for proper operation and service access.

System Layout

Drain Vessels

Connections

Safe Handling of Gas Cylinders

Facilities Requirements

Electrical Requirements

Exhaust and Ventilation Requirements

Venting System Recommendations

Coolant Requirements

Gas Requirements

Argon Gas Requirements

Purity criteria, usage, and connection details for argon gas, the primary torch gas for the ICP-MS.

Cell Gas Requirements

Information on customer-supplied cell gases, purity, and specific requirements for Universal Cell Technology.