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Precision X-Ray X-RAD 160 - User Manual

Precision X-Ray X-RAD 160
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X-RAD
Biological
Irradiator
Precision X-Ray Inc.
15 Commerce Drive
North Branford, CT 06471
203-484-2011
www.PXinc.com
User Manual
This document is to provide a
complete operational description of
the X-RAD Biological Irradiator. This
document is intended for use by
system Users and Super-
Users.
0
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Summary

1 Radiation Protection Information

2 Introduction;System Overview

2.1 Irradiation Cabinet

Enclosure protecting from radiation, compliant with regulations, leakage < 0.2mRem/hr.

2.2 TouchRAD Panel

Features all controls, analog controls/indicators, touchscreen computer for UI.

2.3 TouchRAD User Interface

Touchscreen application to operate all system features like kV, mA, programs, and histories.

2.4 Available Accessories

Options to enhance capabilities, can be retrofitted on existing units.

3 Irradiation Cabinet

3.1 Safety Interlocks

Prevent accidental radiation exposure; if disabled, X-Rays are not permitted or shut off immediately.

3.2 Warning Lamp

Visual notification for users and bystanders indicating X-Rays are being produced.

3.3 Baffle

Lead shielding around port holes to limit irradiation leakage; some models have user-accessible baffles.

4 TouchRAD Panel

4.1 System Key-Switch

Controls system modes: Off, Standby, and On, affecting UI operability and X-Ray production.

4.2 Warning Lamp

Steady yellow light indicating X-Rays are being produced; a secondary indicator not in the safety circuit.

4.3 Emergency Stop

Hardwired button that instantly stops X-Rays when activated by pushing inward.

4.4 Shelf-Switch

Moves the Motorized/Programmable Shelf up/down to adjust source to specimen distance (SSD).

4.5 Touchscreen Computer

Hosts the TouchRAD User Interface; turns on/off via System Key-Switch.

4.6 USB Port

Used for downloading system database and plugging in external Wi-Fi adaptors.

5 TouchRAD User Interface

5.1 Overview

Touchscreen application controlling all system functionality, running exposures, setting routines, etc.

5.2 System Startup

System requires positioning key to STANDBY or ON; UI loads and initializes.

5.3 Logging In

User must log in with username and password to access system functionality; displays User Login Screen.

5.4 Manual Mode

5.4.1 Overview

"Manual Mode" or Program 0 enables custom exposure settings for kV, mA, and time.

5.4.2 Producing X-Rays

Steps to produce X-Rays, including setting parameters, selecting "Continue", and then "X-Rays Start".

5.5 Programs Types

5.5.1 Overview

Defines programs for consistent exposures; allows creating or modifying programs like Time, Dose, etc.

5.5.2 Time Mode

Produces X-Rays at specific kV/mA, ending when a predefined time (5s-99,999s) is reached.

5.5.3 Dose Mode

Produces X-Rays at specific kV/mA, ending when a predefined dose (in cGy) is reached.

5.5.4 Variable Dose Mode

Produces X-Rays at specific kV/mA, ending when a user-defined dose (in cGy) is reached.

5.5.5 Cycle Mode

Repeats On-Off X-Ray cycles for a user-defined number of cycles at specific kV/mA.

5.6 Program Recall

5.6.1 Overview

Recalls pre-defined exposure programs for accurate, consistent results; selects programs from a list.

5.6.2 Recalling a Program

Describes two methods to recall a program: selecting an item or entering it in the entry box.

5.7 Warm-up;Conditioning

5.8 Filter Recognition

5.8.1 Overview

Software automatically detects inserted filters to ensure correct program procedures are followed.

5.8.2 Incorrect Filter

Displays an error if the wrong filter is inserted, indicating the current filter's binary number.

5.9 Motorized Shelf

5.9.1 Overview

User adjusts SSD manually using the Shelf Key-Switch and an on-board scale.

5.10 Programmable Shelf

5.10.1 Overview

Programs SSD and offset automatically through the UI, or manually via the Shelf Key-Switch.

5.11 Specimen Observation System

5.12 Errors

5.12.1 Overview

User may encounter error messages related to safety circuits or system issues during operation.

5.12.2 Error Codes

Lists common error messages, their causes (e.g., Door Open, Emergency Stop), and recommended actions.

6 Maintenance

6.1 Overview

Required for long-term product reliability; operators should inspect the unit and report anomalies.

6.2 Daily Inspection

Quick visual checks performed daily by operators to verify system integrity.

6.3 Annual Maintenance

System maintenance by an authorized engineer ensures proper system performance and longevity.

7 Troubleshooting

7.1 User Interface;X-Ray System Out-of-Sync

Addresses situations where the UI and X-Ray system become unsynchronized, preventing X-Rays.

7.1.1 Diagnosis

Describes symptoms indicating the UI is out of sync with the X-Ray system.

7.1.2 Fix

Steps to resynchronize the TouchRAD User Interface and X-Ray System.

7.2 Safety Circuit Errors

Common errors caused by open safety interlock switches preventing X-Ray production.

7.2.1 Causes

Lists common causes for safety circuit errors, such as door open or emergency stop activation.

7.2.2 Fix

Provides steps to resolve safety circuit errors by checking switches and components.

8 Available Accessories

8.1 Overview

Options available to enhance capabilities, all retrofittable on existing installed units.

8.2 Dose Measurement Control (PN 150010)

Option to specify and terminate exposure based on delivered dose (in Gy) at a known distance.

8.3 X-Ray Beam Conditioning;Hardening Filters with Filter Recognition

Filters that remove undesired low energy photons to improve specimen irradiation and prevent skin irritation.

8.4 Fixed Collimators

Fixed aperture collimators for precisely defining the irradiation field, available in various sizes and shapes.

8.5 Adjustable Collimator

Motorized 4-leaf X-ray field diaphragm to define rectangular or square exposure fields.

8.6 Motorized Shelf (PN XD1602001)

Key-operated stainless steel shelf for quickly setting up exposures and source-to-shelf heights.

8.7 Programmable Shelf (PN XD1602201)

Similar to motorized shelf but with programmable height via TouchRAD control for automatic SSD setting.

8.8 Turntable

Accessory for rotating specimens during irradiation, ensuring uniform exposure.

8.9 Remote Access

Allows remote connection for diagnostics, updates, and troubleshooting by Precision X-Ray service engineers.

8.10 Cabinet Heater (PN XD1608401)

Compact unit to heat the irradiation chamber, maintaining temperatures up to 35°C.

8.11 Environmental Chamber (PN XD1608101)

Designed for introducing and controlling gases in an environmental chamber, with various features for gas control.

8.12 Environmental Chamber Temperature Control (PN XD1608101)

Additional option for the environmental chamber to control temperature via an electrically heated floor/base.

8.13 Pie Cage (PN XD1905005)

Circular cage holding 11 mice for whole body irradiation, with a notched lid for easy insertion/removal.

8.14 Mouse Fixtures;Shields

Restraining fixtures with lead shields for partial body irradiation applications like flank, spine, abdomen, or head exposure.

9 Support

Overview

The X-RAD Biological Irradiator is a sophisticated system designed for precise and controlled X-ray irradiation in biological research. It features a robust radiation enclosure, a touchscreen user interface, and various accessories to enhance its capabilities for diverse experimental needs.

Function Description

The primary function of the X-RAD Biological Irradiator is to produce controlled X-ray radiation for biological specimens. It allows users to manipulate X-ray parameters (kV and mA), run time-dependent or dose-dependent programs, and review exposure histories. The system is designed to provide accurate and consistent exposures, crucial for reproducible research. Safety is paramount, with multiple interlocks and warning systems to prevent accidental radiation exposure.

Important Technical Specifications

Radiation Protection: The irradiation cabinet is a one-piece radiation enclosure manufactured to comply with Federal Regulations CFR1020.40, providing radiation protection with a leakage of less than 0.2mRem/hr at any point on the outside surface.

System Control: The system is controlled via a TouchRAD Panel, which includes analog controls/indicators and a touchscreen computer. The System Key-Switch allows changing the system state between OFF, STANDBY, and ON. An Emergency Stop button instantly halts X-ray production when activated.

X-Ray Parameters: The system allows manipulation of kV and mA settings. Exposure times can be set from a minimum of 5 seconds to a maximum of 99,999 seconds in Time Mode. For Dose Mode, exposures end when a pre-defined dose (in cGy) is reached.

Safety Interlocks: All X-RAD Biological Irradiators are equipped with safety interlocks on the cabinet door and baffle. These interlocks prevent X-ray production if disabled and immediately shut off X-rays if activated during an exposure. A CDRH Switch on the cabinet door physically inhibits X-rays from being produced while the door is open.

Warning Lamp: An "X-Ray On" warning lamp provides visual notification when X-rays are being produced. If the warning lamp fails, X-rays will shut off, and an error will be displayed.

Baffle: The baffle provides lead shielding around the port hole(s) to limit irradiation leakage. Some models feature dedicated user-accessible baffles for running wires, cables, hoses, and equipment into the cabinet without radiation leakage.

Dose Measurement Control (PN 150010) (Optional): This option allows users to specify the actual dose (in Gy) to be delivered and terminates exposure when the dose is reached. It uses a PTW 7862 parallel plate transmission chamber to measure relative dose.

X-Ray Beam Conditioning/Hardening Filters with Filter Recognition (Optional): These filters remove undesired low-energy photons, preventing superficial tissue irritation/burns and delivering only desired photons to the specimen. The system automatically recognizes the inserted filter and displays an error if the wrong filter is used.

Fixed Collimators (Optional): Standard or customized fixed aperture collimators define the irradiation field, with sizes ranging from 0.5cm to 10cm diameter. Specialized shapes are available for specific irradiation needs.

Adjustable Collimator (Optional): A motorized 4-leaf X-ray field diaphragm allows users to define rectangular or square exposure fields from less than 1x1 cm to 20x20 cm at 50 cm FSD.

Motorized Shelf (PN XD1602001) (Optional): A key-operated stainless steel specimen shelf allows manual adjustment of the source-to-specimen distance (SSD) via a Shelf Key-Switch. A scale behind the shelf aids in accurate positioning.

Programmable Shelf (PN XD1602201) (Optional): Similar to the motorized shelf, this option allows automatic setting of SSD and specimen offset through the User Interface for each program. It can also be manually positioned via the Shelf Key-Switch. SSD values are in centimeters and must be whole numbers, not accounting for specimen height (offset must be entered separately).

Turntable (Optional): A motorized turntable ensures uniform irradiation of specimens.

Remote Access (Optional): Allows Precision X-Ray to remotely connect for system diagnostics, updates, and troubleshooting, reducing the need for on-site service calls.

Cabinet Heater (PN XD1608401) (Optional): A wall-mounted, thermostatically controlled ceramic heating unit can heat the irradiation chamber up to 35°C.

Environmental Chamber (PN XD1608101) (Optional): Designed for introducing and controlling gases in an environmental chamber. Features include a CO2 controller and sensor, pressure relief valve, two sensors with three access ports, circulation fan, two gas inlets, pullout sliding shelves, and a humidification tray.

Environmental Chamber Temperature Control (PN XD1608101) (Optional): An additional option for the environmental chamber, allowing thermostatic adjustment of the chamber temperature via an electrically heated floor/base.

Pie Cage (PN XD1905005) (Optional): A circular mouse pie cage designed for whole-body irradiation, capable of holding 11 mice. It has a notched ventilated lid for easy insertion and removal of mice.

Mouse Fixtures/Shields (Optional): Lead-shielded mouse restraining fixtures for various partial body irradiation applications (flank, spine, abdomen, head).

Usage Features

User Interface: The TouchRAD User Interface is a touchscreen-based application controlling all X-RAD system functionalities, including running exposures, setting exposure routines, and administering user accounts.

System Startup: The system starts by positioning the System Key-Switch to STANDBY or ON. The computer automatically boots, and the TouchRAD User Interface loads after initialization (approx. 10 seconds).

Logging In: Users must log in to access system functionalities. The Login Screen requires a username and password, which can be entered via an onscreen keyboard or selected from a dropdown list.

Manual Mode (Program 0): Allows users to run exposures without a predefined program, manipulating kV, mA, and exposure time as needed. Users must confirm filter and SSD settings before starting X-rays.

Program Types:

  • Time Mode: Produces X-rays at specific kV and mA, ending when a pre-defined time (5 to 99,999 seconds) is reached.
  • Dose Mode (with Dose Measurement Control): Produces X-rays at specific kV and mA, ending when a pre-defined dose (in cGy) is reached.
  • Variable Dose Mode (with Dose Measurement Control): Similar to Dose Mode, but the user defines the dose at program start-up.
  • Cycle Mode: Repeats On-Off X-ray cycles for a user-defined number of cycles. On-cycles can be time or dose-based, while Off-cycles are time-based.

Program Recall: Allows users to select and run pre-defined exposure programs for consistent results.

Warm-up/Conditioning: The system automatically determines if an X-ray tube warm-up is required (if no X-rays have been produced within 8 hours). Warm-up ensures the tube is ready for maximum kV and mA production and prevents damage. Exposures cannot be performed until warm-up is complete (typically 20 minutes for 8-96 hours downtime). Weekly warm-ups are highly recommended regardless of usage.

Specimen Observation Camera (Optional): A closed-circuit live feed camera inside the cabinet allows users to monitor specimens before, during, and after an exposure. Crucial X-ray data and an "X-RAYS STOP" button are displayed on the screen.

Error Handling: The system displays error messages for safety circuit issues or X-ray system malfunctions. Users must fix the error and then clear it using the "CLEAR" button before producing X-rays.

Maintenance Features

Daily Inspection: Operators should perform daily visual inspections before use:

  1. Inspect the cabinet, components, and cables for damage or misuse.
  2. Verify no cooling system leaks or fluids on the floor.
  3. Verify the cabinet door closes properly and latching mechanism hardware is secure.
  4. Verify all indicator and warning lights illuminate when X-rays are turned on. Report any malfunctions immediately.

Annual Maintenance: Performed by an authorized Precision X-Ray Engineer to ensure long-term product reliability and performance. The TouchRAD console displays a message when annual maintenance is due. Services include:

  1. High Voltage Interface Maintenance: Cleaning, greasing, and compressing high voltage interfaces at the X-ray tube and generator to prevent damage.
  2. Cooling System Inspection: Checking for leaks, proper fluid levels, coolant discoloration, and safety system functionality.
  3. Cabinet Radiation Survey: Ensuring no radiation leaks exceed factory specifications.
  4. Safety Systems Verification: Inspecting and testing all cabinet safety interlocks for wear and functionality.
  5. Operational Performance Testing: Operating the system at full levels to determine performance, downloading and analyzing history logs, and making necessary adjustments.

Precision X-Ray X-RAD 160 Specifications

General IconGeneral
BrandPrecision X-Ray
ModelX-RAD 160
CategoryIndustrial Equipment
LanguageEnglish

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