MAN-04008-001 Rev. 001 Page 3 of 27
The ThinPrep Sample Preparation Process
(1) Dispersion (2) Cell Collection (3) Cell Transfer
The ThinPrep Pap test filter
rotates within the sample
vial, creating currents in the
fluid that are strong enough
to separate debris and
disperse mucus, but gentle
enough to have no adverse
effect on cell appearance.
A gentle vacuum is
created within the
ThinPrep Pap test filter,
which collects cells on
the exterior surface of
the membrane. Cell
collection is controlled
by the ThinPrep 5000
processor’s software that
monitors the rate of flow
through the ThinPrep
Pap test filter.
After the cells are collected on
the membrane, the ThinPrep Pap
test filter is inverted and gently
pressed against the ThinPrep
microscope slide. Natural
attraction and slight positive air
pressure cause the cells to
adhere to the ThinPrep
microscope slide resulting in an
even distribution of cells in a
defined circular area.
As with conventional Pap smears, slides prepared with the ThinPrep
®
5000 processor are examined in the
context of the patient’s clinical history and information provided by other diagnostic procedures such as
colposcopy, biopsy, and human papillomavirus (HPV) testing, to determine patient management.
The PreservCyt
®
Solution component of the ThinPrep 5000 system is an alternative collection and
transport medium for gynecologic specimens tested with Hologic’s APTIMA COMBO 2
®
CT/NG Assay
and the Digene Hybrid Capture System HPV DNA assay. Refer to the respective manufacturer’s
package inserts for instructions for using PreservCyt Solution for collection, transport, storage, and
preparation of specimens for use in those systems.
The PreservCyt Solution component of the ThinPrep 5000 system is also an alternative collection and
transport medium for gynecologic specimens tested with the Roche Diagnostics COBAS AMPLICOR
TM
CT/NG assay. Refer to Hologic’s labeling (Document #MAN-02063-001) for instructions for using
PreservCyt Solution for collection, transport, storage, and preparation of specimens and to the Roche
Diagnostics COBAS AMPLICOR CT/NG package insert for instructions for use of that system.
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