3
Chapter 1: Introduction
strand by joining the free nucleotide bases to the primers. When
this process is repeated, a strand that was formed with one primer
binds to the other primer, resulting in a new strand that is restricted
solely to the desired segment. Thus, the region of DNA between
the primers is selectively replicated. Further repetitions of the
process can produce billions of copies of a small piece of DNA in
several hours. PCR was developed in 1985 by Kary B. Mullis,
who was awarded the 1993 Nobel Prize in chemistry for his work.
It is used in a broad range of applications from DNA fingerprinting
to medical tests to identify diseases from the infectious agent’s
DNA. See also nucleic acid. The Concise Columbia Encyclopedia
is licensed from Columbia University Press. Copyright © 1995 by
Columbia University Press. All rights reserved.
About This Manual
This manual is designed to help you learn how to install, use, and
maintain your Filtered (PCR) Enclosure.
Chapter 1: Introduction provides a brief overview of the Filtered
PCR Enclosure, explains the organization of the manual, and
defines the typographical conventions used in the manual.
Chapter 2: Prerequisites explains what you need to do to prepare
your site before you install the Filtered PCR Enclosure. Electrical
and service requirements are discussed.
Chapter 3: Getting Started contains the information you need to
properly unpack, inspect, install, and certify the Filtered PCR
Enclosure.
Chapter 4: Performance Features and Safety Precautions explains
how the Purifier Filtered PCR Enclosure operates and the
appropriate precautions you should take when using it.
Chapter 5: Using Your Filtered Enclosure discusses the basic
operation of how to prepare, use and shut down your Filtered PCR
Enclosure.
Chapter 6: Maintaining Your Filtered PCR Enclosure explains
how to perform routine maintenance on the PCR Enclosure.
Chapter 7: Accessorizing Your Filtered PCR Enclosure explains
acceptable modifications to the PCR Enclosure or how to add
accessories.
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