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Waters Xevo TQ-XS Mass Service Manual

Waters Xevo TQ-XS Mass
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Waters Xevo TQ-XS Mass
Spectrometry System
Overview and Maintenance Guide
715004990
Revision A
Copyright © Waters Corporation 2016
All rights reserved

Table of Contents

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Waters Xevo TQ-XS Mass Specifications

General IconGeneral
TypeTriple Quadrupole Mass Spectrometer
PolarityPositive and Negative
Polarity Switching Speed20 ms
Ionization SourceElectrospray Ionization (ESI), Atmospheric Pressure Chemical Ionization (APCI)
Mass Resolution0.7 FWHM
Operating Temperature15-30 °C
Operating Humidity20-80% (non-condensing)

Summary

General information

Contacting Waters

Provides contact details for Waters technical support and general inquiries.

Safety considerations

Considerations specific to the device

Outlines potential hazards and precautions related to the mass spectrometer device.

1 Waters Xevo TQ-XS Overview

1.1 IntelliStart technology

Explains the IntelliStart technology for instrument performance monitoring and setup.

1.2 ACQUITY UPLC/MS Xevo TQ-XS systems

Details compatibility and configuration with ACQUITY UPLC/MS systems.

1.3 Ionization techniques and source probes

Describes various ionization techniques and optional source probes for the system.

1.4 IntelliStart fluidics system

Details the components and operation of the IntelliStart fluidics system.

1.5 Ion optics

Explains the functioning of the mass spectrometer's ion optics.

1.6 MS operating modes

Lists and explains the different MS operating modes.

1.7 MS/MS operating modes

Lists and explains the different MS/MS operating modes available for analysis.

1.10 Rear panel

Details the connectors and controls located on the mass spectrometer's rear panel.

2 Preparing the mass spectrometer for operation

2.1 Preparing to start the mass spectrometer

Steps for preparing the mass spectrometer before powering it on for operation.

2.2 Starting the mass spectrometer

Procedure for powering on and initializing the mass spectrometer and associated software.

2.4 Monitoring the mass spectrometer LEDs

Explains the meaning of the mass spectrometer's LED indicators for operational status.

2.7 Preparing the IntelliStart Fluidics system

Instructions for setting up and preparing the IntelliStart Fluidics system.

2.11 Emergency shutdown of the mass spectrometer

Instructions for safely shutting down the mass spectrometer in an emergency situation.

3 Changing the mode of operation

3.1 Changing the Mode of Operation

Overview of how to prepare the mass spectrometer for different operational modes.

3.2 ESI, ESCi, and APCI modes

Details on configuring and using ESI, ESCi, and APCI ionization modes.

3.3 Combined APPI/APCI source

Information on installing and operating the combined APPI/APCI source.

3.4 UniSpray source

Instructions for installing and removing the UniSpray source.

3.5 NanoFlow ESI source

Information on installing and using the NanoFlow ESI source for low flow rate analysis.

3.6 ionKey source

Describes the installation and use of the ionKey source for integrated UPLC separation.

4 Maintenance procedures

4.1 Maintenance schedule

Outlines periodic maintenance tasks to ensure optimal instrument performance.

4.3 Troubleshooting with Connections INSIGHT

Guidance on using Connections INSIGHT for proactive service and support.

4.4 Safety and handling

General safety precautions and handling guidelines for maintenance procedures.

4.5 Preparing the instrument for working on the source

Procedure to follow before performing operations on or inside the instrument's source.

4.6 Removing and refitting the source enclosure

Steps for removing and fitting the source enclosure on the instrument.

4.7 Operating the source isolation valve

Instructions on how to open and close the source isolation valve.

4.12 Cleaning the source components

Guidance on cleaning various source components for optimal performance.

4.13 Cleaning the sampling cone assembly

Instructions for removing, disassembling, cleaning, and assembling the sampling cone.

4.14 Cleaning the ion block assembly

Steps for cleaning the ion block assembly components.

4.15 Cleaning the StepWave ion guide assembly

Steps for cleaning the StepWave ion guide assembly, including disassembly and reassembly.

4.16 Replacing the probe assembly

Procedure for removing and installing the probe assembly.

4.17 Replacing the ESI probe tip and gasket

Instructions for replacing the ESI probe tip and its associated gasket.

4.19 Replacing the APCI probe heater

Procedure for removing and fitting the APCI probe heater.

4.20 Cleaning or replacing the corona pin

Guidance on cleaning or replacing the corona pin for APCI and ESCi modes.

4.24 APPI/APCI source - changing the UV lamp bulb

Steps for changing the UV lamp bulb in the APPI/APCI source.

4.26 APPI/APCI source - replacing the APPI lamp drive seals

Instructions for replacing the APPI lamp drive assembly O-rings.

4.29 Replacing the fluidic lines of the ionKey source

Procedures for removing and installing fluidic lines for the ionKey source.

4.30 Cleaning the ionKey source and connectors

Steps for cleaning the ionKey source and its connectors.

A Safety advisories

A.1 Warning symbols

Explains the meaning and application of various hazard and warning symbols.

A.5 Warnings that apply to all Waters instruments and devices

General warnings applicable to all Waters instruments and devices.

B External connections

B.1 External wiring and vacuum connections

Details the rear panel connections for external wiring and vacuum systems.

B.2 Connecting the EBARA oil-free roughing pump

Instructions for installing and connecting the EBARA oil-free roughing pump.

B.4 Connecting to the nitrogen gas supply

Procedure for connecting the nitrogen gas supply to the instrument.

B.5 Connecting to the collision cell gas supply

Steps for connecting the collision cell gas supply, including argon requirements.

B.10 Input/output signal connectors

Describes the input/output signal connectors on the mass spectrometer's rear panel.

B.11 Connecting to the electricity source

Guidelines for connecting the instrument to the appropriate electricity source.

C Materials of Construction and Compatible Solvents

C.2 Items exposed to solvent

Lists components exposed to solvents and their materials.

C.3 Solvents used to prepare mobile phases

Details common solvents used for preparing mobile phases for LC/MS.

D IntelliStart Fluidics System Plumbing

D.2 Plumbing schematic

Provides a diagram of the IntelliStart Fluidics system plumbing.

D.3 ionKey and TRIZAIC source plumbing

Illustrates the plumbing connections for ionKey and TRIZAIC sources.

D.4 Tubing specifications

Lists specifications for replacement tubing used in the IntelliStart Fluidics system.

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