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Waters Xevo TQ-S micro User Manual

Waters Xevo TQ-S micro
264 pages
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Waters Xevo TQ-S micro
Overview and Maintenance Guide
715004599/ Revision B
Copyright © Waters Corporation 2014 – 2016
All rights reserved

Table of Contents

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Waters Xevo TQ-S micro Specifications

General IconGeneral
TypeTriple Quadrupole Mass Spectrometer
Scan SpeedUp to 10, 000 Da/sec
SoftwareMassLynx
PolarityPositive and Negative
Ionization SourceESI, APCI, APPI
Mass Range2 to 2048 m/z
Scan ModesMRM, Full Scan, Product Ion Scan, Precursor Ion Scan, Neutral Loss Scan

Summary

General Information

Safety considerations

Covers various hazards and safety notices for instrument operation and maintenance.

Contacting Waters

Provides contact information for technical support and general inquiries.

Operating this instrument

Intended use of the Xevo TQ-S micro

Defines the instrument's purpose as a research tool for quantitative analysis.

Quality control

Outlines routine procedures for ensuring instrument performance and data validity.

1 Specifications and Operating Modes

Uses and compatibility

Details the instrument's capabilities and compatible Waters ZSpray sources.

Ionization techniques and source probes

Introduces various ionization methods used with the instrument.

MS operating modes

Introduces different Mass Spectrometry operating modes.

2 Preparing for Operation

Starting the mass spectrometer

Outlines the procedure for powering on the workstation, instrument, and software.

Emergency shutdown of the mass spectrometer

Provides instructions for safely shutting down the instrument in an emergency.

3 Changing the Mode of Operation

ESI mode

Covers installing and removing an ESI probe for ESI applications.

APCI mode

Details APCI mode for producing singly charged molecules and its interface.

ionKey source

Introduces the ionKey source integrating UPLC separation.

4 Maintenance Procedures

Maintenance schedule

Lists periodic maintenance tasks, frequencies, and information sources.

Safety and handling

Outlines general safety considerations and precautions for maintenance procedures.

Replacing the ESI probe tip and gasket

Covers replacing the ESI probe tip and gasket when blocked or damaged.

A Safety Advisories

Warning symbols

Explains hazard symbols alerting to risks during use or misuse.

Mass spectrometer shock hazard

Warns about electric shock risks and protective panels.

Biohazard and chemical hazard warning

Warns about processing biohazards, corrosive, or toxic materials.

B External Connections

Connecting the oil-filled roughing pump

Required materials and steps to connect the oil-filled roughing pump.

Connecting the Edwards oil-free roughing pump

Steps to connect the alternative oil-free roughing pump.

Connecting to the nitrogen gas supply

Required materials and steps to connect the nitrogen gas supply.

C Materials of Construction and Compliant Solvents

Items exposed to solvent

Lists items exposed to solvent and their materials for safety evaluation.

Solvents used to prepare mobile phases

Lists common ingredients for mobile phases in reverse-phase LC/MS (API).

D Plumbing the IntelliStart Fluidics System

The selector valve

Describes the selector valve's location, etched letters, and port connections.

Tubing and connection specifications

Provides specifications for replacement tubing, nuts, and ferrules.

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