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Millipore Sigma Pellicon 3 Cassettes User Manual

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16 pages
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Contents
Introduction ..................................... 2
Membrane Type ........................... 2
Pump Capacity ............................ 2
Water Quality .............................. 2
Installation ...................................... 2
Pellicon
®
3 88 cm
2
and 0.11 m
2
Cassette Holder Installation ........... 2
Pellicon
®
3 0.57 or 1.14 m
2
Cassette
Benchtop Holder Installation .......... 3
Manual Process-Scale Holder
Installation ................................. 4
Hydraulic Process Scale Holder
Installation ................................. 5
Maintenance ................................... 7
Flushing and Cleaning ....................... 7
Flushing ..................................... 8
Cleaning ..................................... 8
Sanitization ..................................... 9
Depyrogenation .............................. 10
Integrity Testing ............................. 10
Measurement of Normalized Water
Permeability................................... 11
Storage ......................................... 12
Troubleshooting .............................. 14
Warranty ....................................... 15
The life science business of Merck KGaA, Darmstadt,
Germany operates as MilliporeSigma in the U.S. and Canada.
Pellicon
®
3 Cassettes
Installation and User
Guide

Questions and Answers:

Millipore Sigma Pellicon 3 Cassettes Specifications

General IconGeneral
BrandMillipore Sigma
ModelPellicon 3 Cassettes
CategoryWater Filtration Systems
LanguageEnglish

Summary

Introduction and Basic Information

Membrane Type

Describes the different types of membranes available for the filter holder.

Pump Capacity

Guidance on selecting an appropriate pump for operating Pellicon® 3 cassettes.

Water Quality

Recommends specific water types for optimal system performance.

Installation Procedures

Pellicon® 3 88 cm² and 0.11 m² Cassette Holder Installation

Step-by-step guide for installing smaller Pellicon® 3 cassettes in their specific holder.

Pellicon® 3 0.57 or 1.14 m² Cassette Benchtop Holder Installation

Instructions for installing larger Pellicon® 3 cassettes in benchtop holders.

Manual Process-Scale Holder Installation

Procedures for installing Pellicon® 3 cassettes in manual process-scale holders.

Hydraulic Process Scale Holder Installation

Steps for installing Pellicon® 3 cassettes in hydraulic process-scale holders.

Holder Pressurization and Operation

Details on pressurizing and operating the Pellicon® 3 filter holder assembly.

Maintenance and Cleaning

Storage Solution Removal

Procedures for flushing and cleaning the system after shipping.

Preprocess Equilibration

Steps to prepare the system and cassettes for processing via flushing.

Post Process Cleaning

Cleaning and flushing steps performed after product recovery for system maintenance.

Flushing Procedures

Detailed steps for flushing the cassette and system piping with solutions.

Cleaning Procedures

Procedures for cleaning the system when exposed to process fluids.

Sanitization and Depyrogenation

Sanitization

Procedures for sanitizing Pellicon® 3 cassettes after cleaning.

Depyrogenation

Steps for removing pyrogens after cleaning and sanitization.

Integrity Testing and Performance Measurement

Integrity Testing

Methods for testing the integrity of Pellicon® 3 filter systems.

Measurement of Normalized Water Permeability

Procedure for establishing baseline and monitoring water permeability.

Storage

Troubleshooting Guide

Warranty Information