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Millipore Sigma Pellicon 3 Cassettes - Maintenance and Cleaning; Storage Solution Removal; Preprocess Equilibration; Post Process Cleaning

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Pellicon
®
3 Cassettes Installation and User Guide 7
Maintenance
Pellicon
®
3 Cassettes must be operated while under compression from the holder
assembly to ensure that the cassettes will seal properly. The compression is supplied
by applying torque to the nuts on the threaded tie-rods of the holder assembly. If
proper holder maintenance is not performed, higher torque values will be required to
achieve proper sealing.
The following steps are recommended to keep the holders in operational condition:
1. Clean nuts, washers and tie-rods before every use to ensure that they are free of
particles. A mild solvent such as IPA and water is generally effective.
2. Use a few drops of suitable lubricant on the tie-rods and between the nuts and
the washers, whenever permitted. This could be a food grade vegetable oil or
glycerin.
3. Check with your Quality Assurance department before introducing a new
lubricant into your production facility.
4. Protect the tie-rods from receiving any blows that could damage their threads,
which can lead to galling. Particular care should be taken when using a torque
wrench near the tie-rods.
5. Replace any component that is visibly worn or does not spin freely.
6. Rates of wear will vary from system to system, but replacement of nuts and
washers should be considered after every ten installations, to maintain high
sealing force in the holder.
7. When new nuts do not spin freely, refurbish the threaded rods with a 5/8 in–18
die.
8. It is recommended that a set of spare parts be kept on hand at all times.
Flushing and
Cleaning
Flushing and cleaning are required for
following process steps:
Storage Solution Removal
Pre-use flushing and cleaning steps are
performed to remove shipping solution.
A minimum of 60 liters of solution per
m
2
of membrane should be used in a
combination of flushes and recirculation
cleanings.
Preprocess Equilibration
A flushing step is utilized to ensure that
the system and cassettes are properly
prepared for processing. The flushing
solution may be something other than
water depending upon the initial solution
used for the process.
Post Process Cleaning
Cleaning and flushing steps are
performed after product recovery
and is intended to clean and sanitize
the system and restore clean water
permeability and process flux to within
range. Some applications may require
a two-step cleaning procedure. In these
cases it is imperative that the primary
cleaning agent be flushed completely
from the system to avoid potentially
harmful chemical reactions between
cleaning agents. A full cleaning recipe
encompasses a sequence of flushes and
recirculations to achieve regeneration of
the membrane performance, sanitization,