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NCS-3500RS
Thermo Scientific NCS-3500RS User Manual
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Therm
o Scient
ifi
c Dio
nex
Ulti
Mate 3000 S
erie
s
Nano/
Cap S
y
stem NCS
-
3500RS
Nano/Cap Pum
p NCP
-
3200RS
Operating Instructions
(Original Operat
ing Instructions
)
Revision: 2.0
Date:
J
anuary 2016
© 201
6
Thermo Fisher Scientific I
nc.
Doc No. 4820.4101
2
Table of Contents
Default Chapter
3
Table of Contents
3
1 Introduction
9
How to Use this Manual
9
Safety Information
11
Symbols on the Module and in the Manual
11
Safety Precautions
13
Consignes de Sécurité
17
Intended Use
22
Federal Communications Commission (FCC) Note
23
2 Overview
25
Unit Description
25
Module Configurations
27
Overview
27
Combinations of Ultimate 3000 Pumps and Solvent Racks
28
Operating Principle
29
Front Panel Elements
30
Rear Panel
32
Power Switch
33
Fuse Cartridge
33
USB Port
33
Digital I/O
33
Solvent Rack
33
Interior Components
34
Fluid Connections
35
Pump Module
37
Rear Seal Wash System
37
Flow Meter
38
Leak Sensor
40
Purge Valve
40
Inline Filter (Loading Pump)
41
Column Compartment
42
Gas and Humidity Sensors
42
Column Switching Valves
42
Column Identification System (Column ID)
42
Operation from Chromeleon
43
System Wellness, Predictive Performance, and Diagnostics
44
3 Installation
45
Facility Requirements
45
Unpacking
45
Positioning the Module in the Ultimate 3000 Rslcnano System
47
Connecting the Module
49
General Information
49
Connecting the USB Cable
49
Connecting the Power Cord
50
Connecting a Solvent Rack
50
Connecting Devices (Mass Spectrometers) to the Digital I/O-Port
50
Setting up the Module in Chromeleon
51
Loading the USB Driver for the Module
51
Installing the Module
53
Configuring the Module
54
4 Preparation for Operation (Startup)
63
Overview
63
Capillaries and Capillary Routing
65
Connecting and Handling Capillaries
65
Routing Capillaries
68
Solvent Reservoirs
70
General Notes
70
Connecting the Solvent Reservoirs
71
Connecting Drain Tubing
73
Pump Module
75
Setting up the Rear Seal Wash System
75
Flow Meter Settings
77
Purging the Pumps
80
Column Compartment
86
Installing a Column Switching Valve
86
Installing a Separation Column
88
Installing a Trap Column
90
Connecting the Components to the Column Switching Valve
90
Equilibrating the System
91
5 Operation and Maintenance
93
Power-Up
93
Status Screen
94
Pump Module
94
Column Compartment
95
Operation from Chromeleon
96
Connecting to Chromeleon
96
Direct Control
97
Automated Control
100
Function Keys and Menus on the Display
102
Showing the Function Keys
102
Menu
104
Information for Operating the Pump
115
Choosing the Solvents
116
Interdependency of Column Pressure and Maximum Flow Rate
118
Adding Solvents to the Flow Meter Configuration
122
Setting the Flow Rate, Flow Acceleration, and Flow Deceleration
127
Setting the Pressure Limits
128
Recording the Pump Signals
129
Rear Seal Wash System
130
Purging the Pumps
132
Detecting Liquid Leaks in the Pump Module
132
Adjusting the Screen Brightness or Contrast
133
Operating the Degasser of a SRD-3X00 Solvent Rack
133
Information for Operating the Column Compartment
135
Turning on Temperature Control
135
Activating Column Identification (Column ID)
137
Adjusting the Sensitivity of the Gas and Humidity Sensors
138
Recording the Temperature Signal
139
Adjusting the Screen Brightness or Contrast
139
Special Functions in Chromeleon
140
Predictive Performance
140
Diagnostics
142
Ready Temp Delta and Equilibration Time
144
Using the Digital Inputs and Outputs (Digital I/O)
145
Operational Qualification and Performance Qualification
145
Recommendations for Optimally Running Systems (Best Practice)
146
Shutting down the Module
148
Maintenance, and Maintenance and Calibration Intervals
150
General Information
150
Maintenance Intervals
151
Calibration Intervals
152
6 Troubleshooting
153
Overview
153
Pump Block Status Indicator (Loading Pump)
154
Messages on the Pump Display
155
Chromeleon Diagnostics Messages
168
Operating Problems
171
Flow Sensor / Pressure Transducer Diagnostics (NC Pump)
180
Performing a Zero Balance Test (Proflow Flow Meter)
180
Calibrating the Pressure Transducers (Classic Flow Meter)
180
Checking the Compression Values (Loading Pump)
182
7 Service
183
General Notes and Safety Precautions
183
Eliminating Leakage in the Pump Module
185
Removing Gas and Humidity from the Column Compartment
186
Rear Seal Wash System
187
Inspecting the Rear Seal Wash System for Leakage
187
Replacing the Peristaltic Tubing
188
Cleaning the Detector Electrodes
189
Replacing the Check Valve Cartridges
190
Pistons and Piston Seals
192
Visually Inspecting the Pump for Piston Seal Leakage
194
Pump Head and Pistons
196
Replacing the Piston Seals
202
Flow Meter
210
Replacing the Flow Meter
210
Replacing the Flow Selector in a Classic Flow Meter
212
Replacing the Filter Frit in a Proflow Flow Meter
213
Installing and Removing Solvent Shut off Valves
214
Inline Filter (Loading Pump)
216
Checking the Filter Frit for Permeability
216
Replacing the Inline Filter
216
Replacing the Filter Frit in the Loading Pump
217
Replacing the Purge Screw (Loading Pump)
218
Testing the Loading Pump for Leakage
219
Column Switching Valve
221
Replacing the Column Switching Valve
221
Replacing the Valve Stator and Rotor Seal
222
Replacing the Main Power Fuses
224
Updating the Firmware
225
8 Module-Specific Information
227
NC Pump
228
Interior Components (Detailed View)
228
Flow Path
229
Operating Principle
230
Loading Pump (Micro Pump)
234
Interior Components (Detailed View)
234
Flow Path
235
Operating Principle
236
Column Compartment
237
Interior Components
237
Operating Principle
238
9 Proflow Flow Meter Upgrade
239
Modifying the Module with a Proflow Flow Meter
239
Guidelines on Operating the Proflow Flow Meter
242
10 Technical Information
243
11 Accessories, Consumables, and Spare Parts
247
Standard Accessories
247
Optional Accessories
250
Consumables and Spare Parts
251
12 Reference Information
255
Chemical Resistance of PEEK
255
Solvent Miscibility
258
Properties of Common Solvents
259
Safety Information about Flammable Solvents
260
13 Appendix
263
Digital I/O (Pin Assignment)
263
Solvent Rack (Pin Assignment)
264
14 Index
265
4
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Thermo Scientific NCS-3500RS Specifications
General
Brand
Thermo Scientific
Model
NCS-3500RS
Category
Laboratory Equipment
Language
English
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