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Covaris E220 - User Manual

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E/LE-series User Manual 1
For research use only
E and LE-Series
USER MANUAL
an automated, batch system for
high performance sample preparation
using adaptive focused acoustic energy
Product Name: E/LE-series running SonoLab 6.2.4 or later
Product Number: E220, E220x, LE220, E220R, LE220R

Other manuals for Covaris E220

Questions and Answers

  • B
    Beverly GrayAug 18, 2025
    What to do if there is a safety interrupt in Covaris E220 Laboratory Equipment?
    • M
      Megan JohnsonAug 18, 2025
      A safety interrupt in Covaris Laboratory Equipment can occur due to several reasons: 1. The water tank might be misaligned. 2. The door could be open. 3. The STOP button might be depressed. 4. The safety interlock could be bypassed. To resolve this, check the tank alignment, ensure the door is closed properly, and verify the safety interlock.
  • K
    Kayla ThompsonAug 21, 2025
    Why does my Covaris Laboratory Equipment have incorrect positioning?
    • M
      moonmarieAug 21, 2025
      If you're experiencing incorrect positioning or inconsistent treatments with your Covaris Laboratory Equipment, it might be due to a lost home position or system misalignment. To fix this, home the system by selecting “initialize system” from the pull-down menu on the main panel, or by restarting SonoLab.
  • W
    William WilsonAug 23, 2025
    What to do if sample vessel hits the water jet nozzle in Covaris E220 Laboratory Equipment?
    • L
      Lauren SteeleAug 23, 2025
      If the sample vessel hits the water jet nozzle in your Covaris Laboratory Equipment, it could be due to the system losing its home position or an incorrect nozzle position. To solve this: 1. Home the system. 2. Reposition the water jet manually.
  • G
    Grace MuellerAug 26, 2025
    How to fix Covaris Laboratory Equipment error message “Unknown Instrument Type”?
    • P
      plloydAug 26, 2025
      If you receive an “Unknown Instrument Type” error message with your Covaris Laboratory Equipment, it's likely due to incorrectly assigned device COM ports. To fix this, go to C:\Covaris\E-Series v6.2\Program to open the SonoLab configuration file, “SonoLab E-Series.ini”. Replace ComPortMotion=usb with ComPortMotion=COM4 and ComPortSound=usb with ComPortSound=COM3.
  • K
    Kenneth OchoaAug 28, 2025
    What to do if Covaris Laboratory Equipment shows error message that system not shut down correctly?
    • S
      shaunbishopAug 28, 2025
      If you receive an error message stating that the Covaris Laboratory Equipment system was not shut down correctly, it means the SHUT DOWN command in Windows XP was not used before rebooting. Follow the instructions on the screen and use the SHUT DOWN command to resolve this.
  • S
    Susan SimpsonAug 30, 2025
    Why is degassing system not generating bubbles in Covaris E220?
    • L
      Lawrence RichardAug 30, 2025
      If the degassing system in your Covaris Laboratory Equipment isn't generating bubbles, it could be due to: 1. A clogged degassing dip tube. 2. The pump not working. Try these steps: 1. Remove the dip tube and backflush it under running water. 2. Examine the six holes (e.g., using a stereo microscope) to see if they are clogged, and use a pin to unclog them. 3. If the pump still doesn't run, contact Covaris.
  • L
    lamjamesSep 1, 2025
    Why are Dithering and Vertical Sweep values different in Covaris E220?
    • L
      lori29Sep 2, 2025
      If the values for Dithering and Vertical Sweep in your Covaris Laboratory Equipment are different from what you entered, it means the values you entered are larger than the limits for a particular Well Plate. Use lower values to resolve this.
  • B
    Benjamin Jones IIISep 3, 2025
    Why is there a delay in powering degassing pump on/off in Covaris Laboratory Equipment?
    • R
      Rachel MoralesSep 4, 2025
      If you experience a delay in powering the degassing pump on/off in your Covaris Laboratory Equipment, it's likely because a method is currently running. Wait until the method completes before powering the degassing pump on or off.
  • T
    Thomas HamiltonSep 6, 2025
    What to do if the Covaris Laboratory Equipment safety interrupt occurs?
    • R
      robin52Sep 6, 2025
      If a safety interrupt occurs with your Covaris Laboratory Equipment, check the water tank alignment, ensure the door is closed properly, verify the STOP button is not depressed, and make sure the door interlock is correctly engaged.
  • M
    Michelle ThomasSep 8, 2025
    Why is the Covaris Laboratory Equipment homing/initialization not completing successfully?
    • K
      kimberly68Sep 8, 2025
      The homing/initialization of your Covaris Laboratory Equipment may not be completing successfully due to a stage limit switch failure or the stage motor stalling. Ensure nothing obstructs stage movement.

Summary

Universal Precautions

Safety and Equipment Warnings

Safety of Operating Personnel

Safety instructions for personnel operating the equipment.

Preventing Equipment Damage

Guidelines to avoid damaging the instrument during operation.

Covaris System Installation Guide

System Startup and Initial Configuration

Water Bath Setup

Instructions for correctly installing and filling the water bath.

Covaris E;LE Series System Description

Acoustic Transducer

Describes the acoustic transducer and its role in sample treatment.

Covaris E;LE Series System Features

Water Bath and Degassing System

Describes the water bath and the system for removing dissolved gases.

Covaris E;LE Series System Controls

Safety System Functionality

Explains the safety features that protect users from hazards.

SonoLab Main Panel Overview

SonoLab Main Panel Operation

SonoLab Method Editor Interface

SonoLab Method Editor Treatment Parameters

SonoLab Method Editor Parameters and Controls

Covaris System Operation Steps

Degassing the Water Bath

Instructions for degasing the water bath for optimal performance.

Running and Managing Covaris Methods

Running a Method Manually

Steps to load samples and start a treatment method.

Manual Overrides and Halting Methods

How to stop, resume, or abort a running method.

Covaris System Shut-Down Procedures

Covaris System Maintenance Guidelines

Water Bath Maintenance

Recommendations for daily and monthly water bath maintenance.

Transducer Care

Care and handling instructions for the acoustic transducer.

Covaris System Maintenance Procedures

Covaris System Relocation and Reinstallation

Covaris System Troubleshooting Guide

Appendix A: SonoLab Software Installation

Appendix A: SonoLab Software Configuration

Appendix B: Windows 7 Driver Update

Appendix B: Driver Installation Steps

Updating RF Controller Board Driver

Detailed steps for updating the RF Controller Board driver via Device Manager.

Appendix B: Driver Installation (Continued)

Appendix B: Final Driver Verification

Appendix C: Site Preparation and Installation

Appendix D: Humidity and Water Management

Covaris E220 Specifications

General IconGeneral
BrandCovaris
ModelE220
CategoryLaboratory Equipment
LanguageEnglish

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