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Varian 385-LC - User Manual

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Service Manual
FOR
Varian 380-LC & 385-LC
EVAPORATIVE
LIGHT-SCATTERING
DETECTOR
Version 1.0 January 2008
PL0890-0360
Polymer Laboratories Ltd, Now a part of Varian, Inc., Essex Road, Church Stretton,
Shropshire SY6 6AX, UK
Tel +44 (0)1694 723581, Fax +44 (0)1694 722171, Service Tel +44 (0)1694 724333
Polymer Laboratories, Varian, Inc., Amherst Fields Research Park, 160 Old Farm Road,
Amherst, MA 01002, USA Tel +1 413 253 9554, Fax +1 413 253 2476
Polymer Laboratories, Varian B.V., Herculesweg 8, 4339 PL Middelburg,
The Netherlands Tel +31 (0)118 671500, Fax +31 (0)118 671502
Polymer Laboratories, Varian Belgium NV SA, Mechelsesteenweg 362,
2860 St.-Katelijne-Waver, Belgium Tel +32 (0) 15 556460, Fax +32 (0) 15 556186
Polymer Laboratories, Varian Deutschland GmbH, Alsfelder Straße 6,
D-64289 Darmstadt, Germany Tel: +49 (0)6151 7030 Fax: +49 (0)6151 703237
Varian S.A.,7 Avenue des Tropiques, Z.A. Courtaboeuf, B.P. 12
F-91941 Les Ulis Cedex, France Tel +33 1.6986.3838 Fax: +33 1.6928.2308

Table of Contents

Questions and Answers

  • A
    Angela CoxAug 15, 2025
    What to do if Varian 385-LC Security Sensors detect a leak inside the unit?
    • J
      Julia Russell DVMAug 15, 2025
      If the Varian Security Sensors detect a leak inside the unit, it means that solvent vapor has been detected. The suggested solution is to stop the pump.
  • J
    Jacqueline RussellAug 18, 2025
    What should I do if the Varian 385-LC' liquid leak sensor has detected liquid in the drip tray?
    • T
      Thomas WhiteAug 19, 2025
      If the liquid leak sensor in your Varian Security Sensors has detected liquid in the drip tray, it indicates liquid is in the base of the unit. You should stop the pump and investigate the cause.
  • H
    hcarrAug 22, 2025
    Why is there baseline noise in Varian 385-LC Security Sensors and how to fix it?
    • G
      Greg ReyesAug 22, 2025
      Baseline noise in Varian Security Sensors can occur if the particle plume is not sufficiently dried in the evaporator tube. To resolve this, increase the temperature of the evaporator by 10° intervals until the noise is acceptable.
  • A
    Amy HernandezAug 25, 2025
    Why is there baseline noise in Varian 385-LC Security Sensors and how can I resolve it?
    • D
      Donald PerezAug 26, 2025
      Baseline noise in Varian Security Sensors can be caused by poor nebulisation of solvent. Increasing the gas flow rate should resolve this issue.
  • S
    Steven JohnsonAug 28, 2025
    Why is there baseline noise in Varian 385-LC due to pump pulsations, and what is the solution?
    • M
      Michael AndrewsAug 28, 2025
      Baseline noise in Varian Security Sensors can be caused by pump pulsations, especially in microbore applications where low flow rates are used. To fix this, increase the back pressure on the pump by fitting a back pressure regulator between the pump and the injection valve.
  • S
    Stephanie PowellSep 1, 2025
    What causes a Fan Driver IC Thermal Shutdown in Varian 385-LC?
    • M
      Michael SmithSep 1, 2025
      A Fan Driver IC Thermal Shutdown in Varian Security Sensors can be caused by a fault with the circuitry, wires, or the fan itself. No specific solution is provided.
  • B
    Brian LawsonSep 4, 2025
    Why did the fan stop in Varian Security Sensors?
    • T
      Tracy VelazquezSep 4, 2025
      The fan in Varian Security Sensors may have stopped due to a fault with the circuitry, wires, or the fan itself. No specific solution is provided.
  • A
    Ashley SchultzSep 7, 2025
    Why is the air temperature less than or equal to 10°C inside the Varian 385-LC Security Sensors enclosure?
    • C
      Courtney CarrSep 7, 2025
      If the air temperature inside the Varian Security Sensors enclosure is less than or equal to 10°C, it is because the environmental temperature is too cold. No specific solution is provided.
  • T
    tbryantSep 12, 2025
    Why is the air temperature greater than 40°C inside the Varian Security Sensors enclosure?
    • A
      Ariana NelsonSep 12, 2025
      If the air temperature inside the Varian Security Sensors enclosure is greater than 40°C, it is because the environmental temperature is too hot. No specific solution is provided.

Summary

Introduction to Varian ELSD Service Manual

Varian ELSD Safety Precautions

Varian ELSD Installation and Setup Guide

Varian ELSD Site Preparation and Requirements

Environmental, power, and gas supply conditions needed before installation.

Varian ELSD Unpacking and Connections

Steps for unpacking, connecting power, gas, fluid, and data interfaces.

Varian ELSD Detector Installation and Storage

Step-by-step guide for physical installation, initial power-up, and storage procedures.

Optimizing Varian ELSD Detector Performance

Varian ELSD General Setup Considerations

Key factors and precautions for setting up the ELSD for chromatography.

Varian ELSD Key Optimisation Parameters

Adjusting gas flow, evaporator, and nebuliser temperatures for performance.

Varian ELSD Step-by-Step Optimization Procedure

Method for tuning the detector's parameters for best performance and sensitivity.

Repairing the Varian ELSD

Varian ELSD Main Assembly Overview

Identification of major internal components and access points for servicing.

Varian ELSD Nebuliser System Repairs

Procedures for removing, installing, and replacing nebuliser components.

Varian ELSD Evaporator System Repairs

Service procedures for the evaporator assemblies of both Varian ELSD models.

Varian ELSD Optical Assembly Maintenance

Procedures for cleaning and replacing components within the optical detection system.

Varian ELSD Electronics and Firmware Management

Steps for replacing main control boards, power supply, and updating instrument firmware.

Varian ELSD Detector Operation Modes

Varian ELSD Standby Mode Functionality

Description of the instrument's low-power state for setup and idle periods.

Varian ELSD Run Mode Operation

Description of the detector's normal operational mode for analysis.

Varian ELSD Troubleshooting Common Issues

Varian ELSD Instrument Error Code Reference

Table listing error codes, their descriptions, and suggested solutions.

Varian ELSD Common Operational Problems and Solutions

Common operational issues, their causes, and recommended remedies.

Varian 385-LC Specifications

General IconGeneral
BrandVarian
Model385-LC
CategorySecurity Sensors
LanguageEnglish

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