Braun Perfusor Space User Manual

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• TCI by targeting the effect-site concentration
In this mode the user selects the desired concentration of a drug at the site
of action and the PK model is used to calculate the infusion rates required to
achieve that concentration as quick as possible (unless there is no restriction
defined by the user). A certain overshoot of the concentration in the plasma
is resulting from this mode.
For effect-site targeting there is a link between pharmacokinetics and pharma-
codynamics necessary. As the effect-site compartment is considered to have no
volume and the rate constant k
1e
can be ignored the rate constant k
e0
is the
parameter necessary to perform effect-site TCI. A pharmacokinetic model modi-
fied in such way is schematically depicted by the illustration on the next page.
TCI with B. Braun Space is possible with two drugs: Propofol and Remifentanil.
For Propofol the user can choose between two parameter sets. The parameter
sets used for these drugs are (Not all parameter sets allow effect-site targeting):
Chapter 3
SPECIAL FUNCTIONS

Braun Perfusor Space Specifications

General

Device Type	Infusion Pump
Accuracy	±2%
Bolus Rate	Adjustable
Power Supply	100-240 V AC, 50/60 Hz
Display	LCD
Alarms	System error
Occlusion Pressure	Adjustable
Battery Life	Approx. 8 hours at 25 ml/h
Compatibility	B. Braun Space System
Certification	CE
Volume Preselection	0.1 to 9, 999 ml