Sterilizing in Place (SIP)
GMP mixers are designed for SIP.
Sterilization by Pressurized Steam
The mixer can be intermittently operated during the
initial condensate phase of the sterilization sequence
up to 100 °C (212 °F). Recommended maximum speed
of the mixing head is 50 rpm for no longer than 30
seconds.
NOTES
Make sure that condensate lubricates the bearing •
surfaces.
Recommended maximum speed of the mixing head during sterilization is 50 •
rpm.
Turn the mixer off when the temperature reaches 100 °C (212 °F).•
Add liquid before restarting the mixer after sterilization to secure lubrication of •
the bearings.
Magnetic Particles•
a If presence of magnetic particles is suspected, remove the mixing head.
Remove the particles and reinstall the mixing head. (Refer to Male Bearing
Installation, Mixing Head Installation, and Drive Head Installation in this
manual.)
b. Magnetic particles are not removed from the mixing head during CIP; they
must be removed manually or by alternative cleaning. Magnetic particles can
cause corrosion and damage. They can also cause a higher torque, which
may cause the mixing head to decouple and severely damage the vessel.
Other sterilization methods
For information on using other sterilization methods, please contact your Millipore
representative for NovAseptic GMP Mixer product information.Commisioning
26 www.millipore.com
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