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Thermo Scientific LTQ Series Hardware Manual
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TQ
Series
Hardware Manual
97055-9707
2
Revision C
June 2012
2
Table of Contents
Default Chapter
13
Default Chapter
13
Table of Contents
13
Preface
22
Related Documentation
22
Getting a Trap-HCD License
22
Getting a New License Code
23
Installing a New License Code
24
Safety and Special Notices
25
Contacting Us
26
Chapter 1 Introduction
29
LTQ Series Mass Spectrometers
29
Overview of an LC/MS Analysis
32
Chapter 2 Functional Description
35
Overview
35
Figure 1. Functional Block Diagram of an LTQ Series System
36
Syringe Pump
37
Figure 2. Syringe Pump
37
Figure 3. Syringe Pump On/Off Button
37
Divert/Inject Valve
38
Leds and Button
38
Figure 4. Divert/Inject Valve Button and Leds
38
Divert Valve Positions
39
Injection Valve Operation
39
Figure 5. Divert Valve Positions
39
Mass Spectrometer
40
Figure 6. Inject Valve Positions
40
Figure 7. LTQ Series Front Panel Leds
41
Leds
41
Figure 8. Power Panel for the LXQ
42
Figure 9. Power Panel for the LTQ XL and Velos Pro
42
Power Panel
42
API Source
43
Ion Source Interface
43
Figure 10. LXQ Ion Source Interface (Cross Section)
44
Figure 11. LTQ XL Ion Source Interface (Cross Section)
45
Figure 12. Skimmer and Tube Lens (Back View)
46
Figure 13. Velos Pro Ion Source Interface (Cross Section)
46
Figure 14. Velos Pro Exit Lens and S-Lens (Back View)
47
Figure 15. MP00 Rf Lens (LTQ XL on the Left and Velos Pro on the Right)
48
Ion Optics
48
Figure 16. MP0 for the LXQ and LTQ XL
49
Figure 17. MP0 for the LTQ Velos
49
Figure 18. MP0 with a Beam Stop Post for the Velos Pro
49
Figure 19. MP1 Ion Optics
50
Figure 20. LTQ XL Linear Ion Trap Rod Assembly
51
Mass Analyzer
51
Figure 21. Visual Representation of Mass Analyzer Operation
54
Ion Detection Systems
54
Vacuum System
55
Figure 22. Functional Block Diagram of the Vacuum System
56
Figure 23. LXQ Vacuum Manifold with Top Cover Plate and Turbomolecular Pump
57
Figure 24. Turbomolecular Pump
58
Inlet Gases Hardware
59
Cooling Fans
60
Chapter 3 System Shutdown, Startup, and Reset
61
Shutting down the System in an Emergency
61
Opening the Tune Plus Window
62
Figure 25. Tune Plus Window for Velos Pro
62
Placing the Mass Spectrometer in Standby Mode
63
Turning on the Mass Spectrometer
64
Shutting down the Mass Spectrometer Completely
64
Starting the System after a Complete Shutdown
65
Starting the LC System
65
Starting the Data System
66
Starting the Mass Spectrometer
66
Starting the Autosampler
67
Resetting the Mass Spectrometer
67
Resetting Tune and Calibration Parameters
68
Restarting the Data System
69
Turning off Selected Mass Spectrometer Components
69
Chapter 4 Daily Operation
73
Before Operating the LTQ Series System
74
Checking the System Mode
74
Checking the Vacuum Pressure Levels
74
Figure 26. Vacuum Dialog Box
74
Checking the Gas Supplies
76
Checking the ESI Fused-Silica Sample Tube for Elongation
76
After Operating the LTQ Series System
76
Flushing the Sample Transfer Line, Sample Tube, and API Probe
77
Figure 27. APCI Source Dialog Box
77
Figure 28. ESI Source Dialog Box
78
Cleaning the Ion Sweep Cone, Spray Cone, and Ion Transfer Tube
79
Purging the Oil in the Forepump
79
Emptying the Solvent Waste Container
80
Placing the System in Standby Mode
80
Chapter 5 Maintenance
81
Tools and Supplies
83
Ion Source Probe Maintenance
84
ESI Probe Maintenance
85
Figure 29. Two-Piece Fingertight Fitting and Loosened Sample Inlet Adapter Fitting
86
Figure 30. ESI Probe with the Nozzle Removed
88
Figure 31. ESI Nozzle and O-Ring
89
Figure 32. Front End of the ESI Probe (Exploded View)
90
Figure 33. Fused-Silica Sample Tube Inserted through the Front of the ESI Probe
92
Figure 34. Natural PEEK Safety Sleeve Installed in the Sample Inlet (ESI Probe)
93
Figure 35. Natural PEEK Adaptor Fitting Installed to Secure the Safety Sleeve
93
Figure 36. Fingertight Fittings Installed over the Safety Sleeve (ESI Probe)
94
Figure 37. Grounding Union Positioned in the Grounding Bar
94
Figure 38. Safety Sleeve Connection to the Grounding Union (ESI Probe)
95
Figure 39. Sample Tube Securely Tightened to the Grounding Union (ESI Probe)
95
Figure 40. Adjusting the Sample Tube Position (ESI Probe)
96
Figure 41. Sample Tube Position for Flow Rates Greater than 100 Μl/Min (ESI Probe)
96
HESI-II Probe Maintenance
97
Figure 42. Components of the Metal ESI Needle Insert
98
Figure 43. Tip (Enlarged) of the Metal ESI Needle Insert
98
Figure 44. HESI-II Probe Disassembled (Exploded View)
99
Figure 45. HESI-II Probe Nozzle Tip (Enlarged)
99
APCI Probe Maintenance
100
Figure 46. APCI Probe
100
Figure 47. APCI Probe (Cross Section)
101
Figure 48. Sample Inlet End of the APCI Probe Showing Locked and Unlocked
102
Figure 49. APCI Probe Nozzle Assembly
103
Figure 50. 3/8 In. Open-End Wrench on the APCI Flange Fitting
104
Figure 51. APCI Sample Tube Connection
104
Figure 52. Sample Tubing Connection to the APCI Flange Fitting
105
Figure 53. Sample Tube Extending Past the APCI Nozzle Tip
105
Ion Source Interface Maintenance
106
Removing the Ion Source Interface
107
Cleaning the Skimmer and Tube Lens on the LXQ and LTQ XL Mass Spectrometers
108
Figure 54. Ion Source Interface Removed from the Vacuum Manifold
108
Figure 55. Skimmer, Tube Lens, and Ion Source Interface Cage for the LXQ and
109
Cleaning the Exit Lens and S-Lens on the Velos Pro
111
Figure 56. LTQ XL Ion Source Interface Cage
111
Figure 57. Exit Lens, S-Lens, and Ion Source Interface Cage for the Velos Pro
112
Cone
113
Figure 58. Vacuum Dialog Box
114
Figure 59. Inlet Direct Control Dialog Box for an Accela 1250 Pump
114
Figure 60. Ion Sweep Cones
115
Figure 61. Ion Transfer Tube Removal Tool
116
Figure 62. Ion Source Interface Components for the LXQ and LTQ XL
117
Figure 63. Ion Source Interface Components for the Velos Pro
117
Reinstalling the Ion Source Interface
119
MP00 RF Lens Maintenance
119
Removing the MP00 RF Lens Assembly
121
Figure 64. MP00 Rf Lens Assembly Removal
122
Disassembling the MP00 RF Lens Assembly
123
Figure 65. MP00 and Lens L0 Wiring Connections (LTQ XL)
123
Cleaning the MP00 RF Lens Assembly Components
124
Figure 66. MP00 Rf Lens Assembly (LTQ XL)
124
Reassembling the MP00 RF Lens Assembly
125
Reinstalling the MP00 RF Lens Assembly
125
MP0 and MP1 Ion Guides Maintenance
126
Removing the Top Cover of the Mass Spectrometer
127
Figure 67. Front Door Latch
127
Figure 68. Top Cover Screws
128
Figure 69. Top Cover Pushed Back
128
Removing the Vacuum Manifold's Top Cover Plate
129
Figure 70. Electrical Connections to the Top Cover Plate of the Vacuum Manifold
129
Removing the MP0 and MP1 Ion Guides
130
Figure 71. MP0 and MP1 Ion Guides for the LXQ (Exploded View)
132
Figure 72. MP0 and MP1 Ion Guides for the LTQ XL (Exploded View)
133
Figure 73. MP0 and MP1 Ion Guides for the LTQ Velos (Exploded View)
134
Figure 74. MP0 and MP1 Ion Guides for the Velos Pro (Exploded View)
135
Gate Lens
136
Reinstalling the MP0 and MP1 Ion Guides
137
Figure 75. LXQ Wiring Diagram for the MP0 and MP1 Ion Guides
139
Figure 76. LTQ XL Wiring Diagram for the MP0 and MP1 Ion Guides
140
Figure 77. Velos Pro Wiring Diagram for the MP0 and MP1 Ion Guides
141
Reinstalling the Vacuum Manifold's Top Cover
142
Reinstalling the Top Cover of the Mass Spectrometer
143
Electron Multiplier Replacement
143
Figure 78. Electron Multipliers and Dual Anode (LTQ XL)
145
Figure 79. Electron Multipliers and Shield Retainers (Velos Pro)
145
Figure 80. Placement of Screws for the Left and Right Electron Multipliers (Top View)
146
Figure 81. Placement of the Electron Multipliers and Shield Retainers on the Top
146
Figure 82. Diagnostics Dialog Box Showing the Set Device List
147
Figure 83. Diagnostics Dialog Box Showing the Electron Multiplier Voltage Parameters
148
Figure 84. Diagnostics Dialog Box Showing the Mass Calibration Page
149
Figure 85. Calibrate Dialog Box Showing the Automatic Page
150
Figure 86. Semi-Automatic Page in the Calibrate Dialog Box (LXQ and LTQ XL)
151
Figure 87. Semi-Automatic Page in the Calibrate Dialog Box (Velos Pro)
151
Forepump Maintenance
152
Fan Filter Maintenance
152
Chapter 6 Diagnostics
153
Running General Diagnostic Tests
153
Figure 88. Diagnostics Dialog Box Showing the General Test Page
154
Using the Diagnostic Tools
155
Running System Evaluation Tools
155
Figure 89. Diagnostics Dialog Box Showing the System Evaluation Tools Page
155
System Evaluation Tools
156
Chapter 7 Replaceable Parts
159
MS Setup Kit
160
Accessory Kits
160
Chemical Kit
160
Ion Source Probes and Parts
160
Ion Source Interface Parts
161
MP00 Lens Parts
162
MP0 and MP1 Ion Guide Parts
162
Electron Multipliers
163
Miscellaneous Parts
163
Fittings
163
Forepumps
164
Vacuum Manifold Parts
164
Glossary
165
Index
169
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Thermo Scientific LTQ Series Specifications
General
Brand
Thermo Scientific
Model
LTQ Series
Category
Laboratory Equipment
Language
English
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