32 Series 31XX, 32XX Furnaces | Appendix A: SDS Information
8
Results: No effects were seen in an OECD 421 screening study. There are no reports of any reproductive toxic
effects of mineral fibers. Exposure to these fibers is via inhalation and effects seen are in the lung. Clearance
of fibers is via the gut and the feces, so exposure of the reproductive organs is extremely unlikely.
STOT-Single exposure
Not applicable
STOT-Repeated exposure
Not applicable
spiration hazar
Not applicable
See the following review publications for a summary and discussion
:
Interpretation of these animal experiments is complex and there is not complete agreement amongst scientists
internationally.
summary of the evidence relating to RCF carcinogenicity in vivo can be found in SCOE
/SUM/165
and in Utell and Maxim 2010.
Other information
Numerous studies indicate the relevance of biopersistence as a determinant of toxic effects of fiber exposure.
(Maxim et al 2006).
Irritant Properties
Negative results have been obtained in animal studies (EU method B 4) for skin irritation. Inhalation exposures using
the nose only route produce simultaneous heavy exposures to the eyes, but no reports of excess eye irritation exist.
nimals exposed by inhalation similarly show no evidence of respiratory tract irritatio
.
Human data confirm that only mechanical irritation, resulting in itching, occurs in humans. Screening at
manufacturers’ plants in the UK has failed to show any human cases of skin conditions related to fiber exposure.
(e) International Agency for Research on Cancer and National Toxicology Program
IARC, in 1988, Monograph v.43 (and later reaffirmed in 2002, v.81), classified RCF as possibly carcinogenic to
humans (group 2B). IARC evaluated the possible health effects of RCF as follows:
There is inadequate evidence in humans for the carcinogenicity of RCF.
There is sufficient evidence in experimental animals for the carcinogenicity of RCF.
The Annual Report on Carcinogens (latest edition), prepared by NTP, classified respirable RCF as "reasonably
anticipated" to be a carcinogen).
Not classified by OSHA.
12. ECOLOGICAL INFORMATION (Non-mandatory)
(a) Ecotoxicity (aquatic and
terrestrial, where available)
No known aquatic toxicity.
(b) Persistence and degradability
These products are insoluble materials that remain stable over time and are
chemically identical to inorganic compounds found in the soil and sediment;
they remain inert in the natural environment.
(c) Bioaccumulative potential
No bioaccumulative potential.
(d) Mobility in soil
No mobility in soil.
(e) Other adverse effects (such as
hazardous to the ozone layer)
No adverse effects of this material on the environment are anticipated.
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