Millipore Pellicon Single Pass TFF - Cleaning

Pellicon
®
Single Pass TFF Accessories Installation and User Guide 19
Cleaning
To select a cleaning method, identify the application or suspected
foulant from the Cleaning Conditions section of the appropriate
cassette user guide. Select the cleaning agent or agents compatible
with the membrane type and application requirements.
Sanitization, depyrogenation and storage agents are chosen
similarly. In many instances, sanitization and depyrogenation may
be accomplished in the same step. Some applications require a
two-step cleaning procedure. In these cases, it is imperative that
the primary cleaning agent be flushed completely from the system
to avoid potentially harmful chemical reactions between cleaning
agents.
The cleaning step should be run at a feed flow rate of 1–4 L/min/m
2
with the retentate valve partially closed to achieve a conversion of
30–90%. The retentate and permeate lines should be directed to
drain.
1. Flush until a total of approximately 15-30 liters of cleaning
solution per m² of installed filter area have been pumped
through the system and out to drain. Alternatively, the flush
can continue until the retentate and permeate conductivities
approach the conductivity of the feed solution.
2. Turn off the pump, close the retentate and permeate valves,
and allow the system to soak in the cleaning solution for
the duration noted in the Cleaning Conditions section of the
appropriate user guide. At the end of the final soak, pump the
cleaning solution to drain to empty the flow path piping.
NOTE
All surfaces exposed to process fluids should also be
exposed to the cleaning solution. It is good practice to cycle
(partially open and partially close) the valves at least twice
during the cleaning cycle to ensure that all wetted internal
surfaces of the valve body are exposed to the cleaning
solution.
3. Flush the filter with water using the same feed flow rate and
conversion conditions. Flush a total of approximately 15-30
liters of water per square meter of installed filter area through
the system to drain. Alternatively, the flush can continue until
retentate and permeate conductivity reaches an acceptable
target.