REPLIGEN TangenX PRO PD Compatibility Guide

IF.PUG.012 R3
INTRODUCTION
Tangential flow filtration cassettes are typically installed in a stainless steel
cassette holder consisting of two steel plates, one acting as a flow distribution
manifold and the other as a mating solid flat surface. Repligen offers a complete
series of high performance stainless steel cassette holders and are designed for
optimal performance with TangenX™ PRO PD cassettes. In addition to TangenX™
cassette holders, TangenX™ PRO PD cassettes have been designed to be
compatible with other types from alternative manufacturers. The following guide
will outline the compatibility of the TangenX™ PRO PD cassettes with these other
types of cassette holders and act as a supplement to the standard user guide.
TANGENX™ PRO PD CASSETTES
• TangenX™ PRO PD cassettes are offered with two different notch patterns on
the end of the cassette. One has notches located the 0.850in (21.59mm) from
the edge and the other with notches located 0.756in (19.21mm) from the
edge.
• Initially identify which type of corresponding bolt pattern the intended
cassette holder uses. The following is a partial list of cassette holders and
their bolt pattern offset measurement.
o 0.850in (21.59mm) Offset
TangenX™ PRO Holder (TX002, TX003)
Pall – Centramate Holder (CM018LV, FS001K10)
o 0.756in (19.21mm) Offset
Millipore – Pellicon Mini Holder (XX42PMINI)
Sartorius – Sartocon Slice Holder (17525—01, 17521—02)
GE – Kvick Lab Holder (KLPH01SSU, KLHR0105000SS)
FIGURE 1
• Once the cassette holder’s offset bolt pattern has been identified, confirm the
cassette matches the bolt pattern and continue to the next section for the
supplemental guide to the standard user guide.
• Only use the gaskets provided by Repligen that are supplied with each
TangenX™ PRO PD cassette.
TANGENX™ PRO PD CASSETTE | SUPPLEMENTAL INSTALLATION
• Pall Centramate Cassette Holder
Reference TangenX™ User Guide
IF.PUG.003 for basic cassette installation
instructions, further details are below.
The Pall Centramate cassette holder
uses 0.850in (21.59mm) notch pattern
and is compatible with all TangenX™
PRO PD cassettes with the part number
xxxxxAxxx. There are two points of
interest to be aware of when installing
TangenX™ PRO cassette in the
Centramate holder.
The TangenX™ PRO PD cassette must be placed in the cassette holder with
the cassette’s identification label facing “down” or towards the lower flow-
path manifold and away from the brass retaining nuts.
The Centramate cassette holder has four bolts (vs. two), thus reducing the
required torque required to seal the TangenX™ PRO PD cassette. The
corrected torque values are shown in Table 1 below. Tighten the two center
bolts and then the two outer bolts in ¼ turn increments until the
recommended torque is achieved.
Table 1 Recommended Torque Values | Pall Centramate 4-Bolt Holder
Holder Part Number
Torque Range (in-lbs)
Torque Range (Nm)
CM018LV 60 - 90 7 - 10
FS001K10 60 - 90 7 - 10
• GE Kvick Lab Cassette Holder
Reference TangenX™ User Guide IF.PUG.003
for basic cassette installation instructions,
further details are below.
The Kvick packet holder uses the 0.756in
(19.21mm) notch pattern while using 4 bolts
to secure the assembly. The Kvick lab
cassette holder uses the same bolt pattern,
but uses only 2 bolts to secure the
assembly. Both are compatible with all
TangenX™ PRO PD cassettes with the part
number xxxxxWxxx.
The TangenX™ PRO cassette must be placed in the cassette holder with the
identification label facing away from the feed/retentate ports and towards
the brass retaining nuts. The recommended torque values are shown below.
Table 2 Recommended Torque Values | GE Kvick Holder
Holder Part Number
Torque Range (in-lbs)
Torque Range (Nm)
KLPH001SSU (4 Bolt)
60 - 90
7 - 10
KLHR0105000SS (2 Bolt)
120 - 180
14 - 20
• Millipore Pellicon Mini Cassette Holder
Reference TangenX™ User Guide IF.PUG.003 for
basic cassette installation instructions. The
Millipore Pellicon Mini cassette holder uses the
0.756in (19.21mm) notch pattern and is
compatible with all TangenX™ PRO PD cassettes
with the part number xxxxxWxxx.
The TangenX™ PRO PD cassette must be placed in
the cassette holder with the identification label
facing away from the feed/retentate ports and
towards the brass retaining nuts. The
recommended torque values are shown below.
Table 3 Recommended Torque Values | Millipore Pellicon Mini 2-Bolt
Holder Part Number
Torque Range (in-lbs)
Torque Range (Nm)
XX42PMINI 120-180 14-20
• Sartorius Sartocon Slice Cassette Holder
Reference TangenX™ User Guide IF.PUG.003 for
basic cassette installation instructions, further
details are below.
The Sartorius Sartocon cassette holder uses the
0.756in (19.21mm) notch pattern and is
compatible with all TangenX™ PRO PD cassettes
with the part number xxxxxWxxx. The TangenX™
PRO PD cassette must be placed in the cassette
holder with the identification label facing away
from the feed/retentate ports and towards the
brass retaining nuts. The recommended torque
values are shown in Table 4.
Table 4 Recommended Torque Values | Sartorius Sartocon Slice 2-Bolt
Holder Part Number
Torque Range (in-lbs)
Torque Range (Nm)
17525-- 01
120 - 180
14 - 20
17521-- 02
120 - 180
14 - 20
• TangenX™ PRO Cassette Holder
Follow the instructions outlined in
the TangenX™ User Guide
IF.PUG.003 for cassette installation
procedures. A copy is included in
the box of every TangenX™ PRO
cassette.
Every TangenX™ PRO PD cassette
holder uses the 0.850in (21.59mm)
bold pattern and are ideally
compatible with all TangenX™ PRO
PD cassettes with the part number xxxxxAxxx.

REPLIGEN TangenX PRO PD Specifications

General

Brand	REPLIGEN
Model	TangenX PRO PD
Category	Laboratory Equipment
Language	English