REPLIGEN XCell ATF10

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XCell

ATF System with C410:V4B Controller User Guide

Figure 4d. Exploded View of XCell™ ATF 6 Single-use Device with 0.2u PES Hollow Fiber Filter

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Default Chapter3
- Table of Contents3
1 Description of the Xcell™ ATF (Alternating Tangential Flow) System and Process5
- Xcell TM ATF System Pump Cycle7
- Xcell™ ATF System Control Scope and Objectives9
2 Utility Requirements9
3 Dimensions and Weight10
4 Xcell™ ATF Pump Housing Assemblies11
See Appendix 7 for List of Spares and Accessories16
5 Xcell TM C410V4B Controller Layout21
- General Layout21
- Filtration Assembly (Stainless Steel)22
- Pneumatics Box (P-Box) Components22
- Electrical Box (E-Box)22
- Power Box (Power Separation) Components24
- Primary Pneumatic Services24
- Primary Electric Services25
- Signal25
6 C410V4B Controller Process and Control26
- Control Overview26
- Control Functional Algorithms28
- Interface and Screens29
- Startup54
- Examples56
7 Xcell™ ATF Hollow Fiber Module and Diaphragm Replacement58
- Separating the Filtration Assembly from the Bioreactor58
- HFM Removal58
- HFM Insertion59
- Screen Module Replacement60
- Diaphragm Replacement60
- Assembly61
- Use61
8 Sterilization62
- Preparation of Filtration Assembly for Autoclaving62
- Autoclave Cycle63
- Sterilization of Filtrate / Harvest Line64
9 Connection to Bioreactor (ATF-To-Bioreactor)65
- Hard Connection65
10 Maintenance66
- Diaphragm66
- Pump Air Inlet Filter66
- O" Rings, Gaskets and Quick Connects66
Appendix 1: Cycle Time Vs. Flow Rate67
Appendix 2: Access Levels to the C410V4B Controller68
Appendix 3: Controller Lists: Alarm, Warning, Inputs & Outputs75
Appendix 4: Profinet Communication77
Appendix 5: Profibus Communication79
Appendix 6: Delta V Example Configuration100
Appendix 7: OPC Communication107
Appendix 8: Audit Trail (if Equipped)117
Appendix 9: EU Declaration of Conformity120
Appendix 10: UL Listing123
Appendix 11: Spares List124

REPLIGEN XCell ATF10

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