Thermo Scientific ISQ EC User Manual

ISQ EC and ISQ EM
Mass Spectrometer
Operating Manual
1R120591-0002 Revision E • February 2019

Thermo Scientific ISQ EC Specifications

General

Brand	Thermo Scientific
Model	ISQ EC
Category	Laboratory Equipment
Language	English

Summary

Using this Manual

About this Manual

Describes the purpose, features, and layout of the manual, including safety information.

Conventions Used in the Manual

Explains safety messages, notices, and typographical conventions used in the manual.

Reference Documentation

Lists hardware and software documentation available for reference.

Safety

Safety Symbols and Signal Words

Explains safety symbols, signal words, and their meanings used in the manual and on the instrument.

Intended Use and Safety Precautions

Outlines intended use, general safety, personnel qualifications, PPE, electrical, and residual hazards.

Solvent and Additive Information

Provides recommendations for using solvents and additives to maintain instrument functionality.

Compliance Information

Details compliance with domestic and international EMC and safety standards.

Instrument Overview

Mass Spectrometer Operating Principle

Explains the fundamental principle of mass spectrometry and its application in the instrument.

LC/MS or IC/MS Analysis Workflow

Describes the typical workflow of LC-MS or IC-MS analysis and sample introduction methods.

Software Operation with Chromeleon

Details the operation of the instrument using Chromeleon software for control and data management.

Unpacking and Scope of Delivery

Instrument Unpacking Procedures

Provides instructions for inspecting the instrument upon arrival and safe unpacking procedures.

Scope of Delivery Contents

Lists the items included in the delivery of the ISQ EC or ISQ EM system.

Installation

Safety Guidelines for Installation

Outlines essential safety guidelines and precautions to follow during instrument installation.

Installing the Mass Spectrometer

Details the steps for installing the mass spectrometer, including software configuration and qualification.

Site and Environmental Requirements

Specifies the environmental and physical requirements for the installation site, including workbench, power, gas, and ventilation.

Instrument Unpacking and Hardware Setup

Guides through unpacking the instrument and setting up essential hardware components like the pump and filter.

Connecting System Components and Powering Up

Details connecting the system to the PC and the procedure for powering up the instrument.

Summary of Hardware Installation

Provides a step-by-step overview of the complete hardware installation procedure.

Operation

Safety Guidelines for Instrument Operation

Highlights critical safety guidelines specific to operating the mass spectrometer.

MS Instrument Overview and Fluidics

Provides an overview of the MS instrument and its fluidic connections.

Configuring the MS in Chromeleon Software

Details the process of configuring the mass spectrometer within the Chromeleon software.

Chromeleon User Interface and Operation Modes

Describes the Chromeleon interface, ePanels, and instrument operation modes like Real Time Scan and Autotune.

Method Editor and Data Analysis Tools

Guides on using the method editor for configuration and development, plus data signal channels and audit trail.

Shutting Down and Venting the MS Instrument

Provides instructions for safely shutting down, placing in standby, and venting the mass spectrometer.

Remote Start Cable Connections for Synchronization

Describes the use of remote start cables for hardware synchronization with other modules.

Maintenance and Service

Safety and General Rules for Maintenance

Outlines critical safety guidelines and general rules for performing maintenance and service tasks.

Routine, Preventive Maintenance, and Cleaning

Covers routine checks, preventive measures, and procedures for cleaning and decontaminating the instrument.

Probe and Needle Replacement Procedures

Guides through replacing ESI and APCI probe capillaries and APCI needles.

Cleaning the Front Optics Assembly

Explains how to remove and clean the front optics of the mass spectrometer.

Removing and Updating the Instrument

Details procedures for removing the instrument from a stack and updating its firmware.

Troubleshooting

General Troubleshooting Information

Outlines features and general information helpful for identifying and resolving instrument problems.

Troubleshooting Autotune Procedure Issues

Provides a table to diagnose and solve common problems encountered during the autotune process.

Troubleshooting Leaky Source Gases

Guides on how to troubleshoot issues related to leaky source gases, including tightening spray chamber pins.

Specifications

Physical Specifications of the Mass Spectrometer

Lists the physical specifications of the ISQ EC and ISQ EM mass spectrometers.

Accessories, Consumables, and Replacement Parts

General Information on Parts and Accessories

Provides general information about using authorized replacement parts and components.

Ship Kit Contents and Part Numbers

Lists the items included in the instrument's ship kit for initial setup and use.

Orderable Replacement Parts List

Lists parts that can be ordered and installed by the user for maintenance and repair.

Appendix

Compliance Information and Declarations

Provides information on CE, RoHS, WEEE, FCC, and other regulatory compliance.

Manual Release History

Lists the revision history of the manual, including release dates and covered models.