ADCMDP180051 – Date of Preparation March 2018
FreeStyle, Libre and related brand marks are trademarks of Abbott Diabetes Care Inc. in various jurisdictions
• The FreeStyle Libre system measures
glucose in the interstitial fluid, or ISF
(the fluid between the body’s cells).
• Glucose in ISF has been shown to be a
reliable indicator of glucose levels in
blood because glucose freely diffuses
from capillaries to the interstitial space.
1
• The FreeStyle Libre sensor contains
glucose-sensitive reagents that
measure glucose in the ISF
continuously.
• Glucose diffusion between capillary and
ISF is shown to have a short lag of 5-10
minutes.
2
Monitoring Glucose with Interstitial Fluid
1. Rebrin K, Steil GM. Can interstitial glucose assessment replace blood glucose measurements? Diabetes Technology Ther.
2000;2(3):461-472.
2. Rebrin K, Sheppard NF Jr, Steil, GM. Use of subcutaneous interstitial fluid glucose to estimate blood glucose: Revisiting delay and
sensor offset. J Diabetes Sci Technol. 2010;4(5): 1087-1098.
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