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Agilent InfinityLab LC Series Multicolumn Thermostats User Manual 22

1 Introduction to the Multicolumn Thermostat

Typical Applications

Alternating Column Regeneration

(2-position/10-port valves only)

Advantages:

• High sample throughput

• Increased productivity

• High efficiency

Gradient elution is frequently used for fast separation of complex samples in LC.

Since the gradient elution requires the column to regenerate before subsequent

runs, an automated column regeneration system saves valuable analysis time.

Agilent's InfinityLab Quick Change 2-position/10-port valve enables the

simultaneous analysis of one sample on one LC column while an extra

regeneration pump flushes and equilibrates a second, identical column. At the

end of the run, the valve switches to the second position and the next sample is

separated on the previously flushed and equilibrated column. Meanwhile, the

regeneration pump flushes and equilibrates the first column. Up to 50 % of

analysis time is often required to equilibrate columns. Using alternating column

regeneration saves time and provides higher sample throughput.

Column 2

Column 1

Eluent pump /

Autosampler

Regeneration

pump

Waste

Detector

Position 1-10