What to do if a system fault has occurred in SCIEX 5500 Laboratory Equipment because the vacuum pressure is too high?
A system fault in your SCIEX Laboratory Equipment due to high vacuum pressure can be caused by: * Low roughing pump oil level: Inspect the roughing pump oil level. * Leaks: Inspect and repair any leaks. * Incorrect orifice plate: Install the correct orifice plate.
Why has the mass spectrometer performance degraded in my SCIEX 5500?
Degraded mass spectrometer performance in your SCIEX Laboratory Equipment can be due to: * The probe not being optimized: Optimize the probe. * Incorrect sample preparation or sample degradation: Confirm that the sample was prepared correctly. * Leaking sample inlet fittings: Verify that the fittings are the right size and type and make sure that they are tight. Do not overtighten the fittings. Replace the fittings if leaks continue. * Consider installing and optimizing an alternate ion source.
What to do if Analyst software reports a fault status for the mass spectrometer due to the ion source in SCIEX 5500 Laboratory Equipment?
If the Analyst software reports that the mass spectrometer is in Fault status because of the ion source on your SCIEX Laboratory Equipment: * Confirm the fault in the Status panel of the device details page. * The probe may not be installed or connected securely: Install the probe. * Remove and replace the probe and tighten the retaining ring securely.
What causes a non-uniform spray in SCIEX 5500?
If the spray is not uniform in your SCIEX Laboratory Equipment, it may be because the electrode is blocked. Clean or replace the electrode.
Why are arcing or sparks occurring in my SCIEX Laboratory Equipment?
If arcing or sparks occur in your SCIEX Laboratory Equipment, the position of the corona discharge needle may be incorrect. Turn the corona discharge needle toward the curtain plate, and away from the stream of heater gas.
Why is the sensitivity reduced in my SCIEX Laboratory Equipment?
Reduced sensitivity in your SCIEX Laboratory Equipment can stem from several causes: * Ion source parameters might not be optimized: Optimize the ion source parameters. * The syringe or sample line may be leaking: Inspect the syringe or sample line for leaks, and repair any leaks found. Also, make sure that all fittings are the correct type and size. * The sample has degraded or has a low concentration: Verify the sample concentration and use a fresh sample. * The probe is not installed properly: Remove and install the probe. * The ion source is not installed properly, or it is faulty: Remove and install the ion source, making sure that the latches are properly secured. * One or more of the O-rings on the vacuum interface is missing: If the O-rings are on the ion source, then ...
Provides safety precautions for preventing personal injury and system damage.
Details warnings and procedures related to electrical hazards and safe practices.
Outlines hazards and safety measures for handling chemicals used with the system.
Covers safety procedures for venting fumes and ensuring proper air exchange.
Details safety measures related to the system's operating environment and potential hazards.
Specifies requirements for personnel involved in system installation and maintenance.
Warns against improper use, modification, and highlights safety hazards.
Explains the fundamental principles of how the mass spectrometer operates.
Provides instructions and safety warnings for starting the instrument.
Details steps for safely shutting down and venting the system.
Step-by-step guide to creating a new hardware profile for the system.
Describes how to verify or adjust the mass spectrometer's performance.
Details MS/MS optimization using infusion with known precursor and unknown product ions.
Guides users through automatic optimization using Flow Injection Analysis (FIA).
Step-by-step guide to creating acquisition methods using the editor.
Explains different mass spectrometry scan types used in acquisition.
Explains the process of determining substance concentration in samples.
Describes parameters used to generate peaks and calculate concentrations.
Detailed steps for creating quantitation methods using the editor.
Guide to generating a results table using the Quantitation Wizard.
Procedures for reviewing and manually integrating peaks in chromatograms.
Explains how calibration curves are generated and used for sample concentration.
Instructions for generating custom reports using the Reporter software.
Workflow for creating, adding samples, and submitting batches for acquisition.
Steps to equilibrate the mass spectrometer before starting sample acquisition.
Instructions for starting the sample acquisition process.
Provides a recommended schedule for cleaning and maintaining the system.
A table listing common system issues, their causes, and corrective actions.
Step-by-step guide to manually optimize compound-dependent parameters.
Instructions for optimizing MS-specific parameters like DP and EP.
How to identify and select product ions for optimization.
Procedure for optimizing the Collision Cell Exit Potential (CXP).
Steps for manually optimizing ion source and gas settings for optimal performance.
General| Type | Triple Quadrupole Mass Spectrometer |
|---|---|
| Scan Speed | Up to 10, 000 Da/sec |
| Dynamic Range | > 5 orders of magnitude |
| Mass Analyzer Type | Triple Quadrupole |
| Polarity | Positive / Negative |
| Power Requirements | 200 – 240 VAC |
| Resolution | Unit resolution (0.7 FWHM) |
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