SCIEX ZenoTOF 7600 User Manual (English)

Questions and Answers:

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Susan MayAug 22, 2025
Why is my SCIEX ZenoTOF 7600 mass spectrometer performance degraded?
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  steven30Aug 22, 2025
  The degradation in your mass spectrometer's performance could be due to several reasons: * The ion source conditions might not be optimal. In this case, optimize the ion source conditions and clean or replace the electrode. * The sample might not have been prepared correctly or has degraded. Verify the sample preparation. * The sample inlet fittings could be leaking. Ensure the fittings are the correct size and type, and tighten them properly (but avoid overtightening). Replace the fittings if leaks persist. If the issue continues, consider installing and optimizing an alternate ion source. If problems still persist, further assistance may be needed.
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Mercedes MartinezSep 1, 2025
How to resolve a high QPS exciter module temperature fault in SCIEX ZenoTOF 7600?
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  Cynthia RobersonSep 1, 2025
  A system fault caused by a high QPS exciter module temperature on your SCIEX Laboratory Equipment may be due to a high ambient temperature. Contact the local FSE.
S
shannonblairAug 31, 2025
What to do if my SCIEX ZenoTOF 7600 indicates the wrong probe is in use?
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  Raven BrownAug 31, 2025
  If the control software indicates that the APCI probe is in use, but the TurboIonSpray probe is installed, contact an FSE, because the F3 fuse may be blown.
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Maria SmallAug 30, 2025
How to address arcing or sparks in SCIEX ZenoTOF 7600 Laboratory Equipment?
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  Julia ThomasAug 30, 2025
  If you're experiencing arcing or sparks with your SCIEX Laboratory Equipment, and you are using the TurboIonSpray probe, turn the corona discharge needle toward the curtain plate and away from the stream of heater gas.
J
Jennifer HodgeAug 28, 2025
Why won't my SCIEX ZenoTOF 7600 Laboratory Equipment mass spectrometer pump down to the correct base pressure?
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  Benjamin MoonAug 28, 2025
  If the mass spectrometer does not pump down to the correct base pressure, there may be a leak in the area of the orifice plate. Remove and then reinstall the orifice plate, or replace it if it is cracked. Also, inspect all vacuum connections and vacuum seals.
X
xrichardsonAug 27, 2025
How to improve spray uniformity in SCIEX ZenoTOF 7600?
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  Madison MillerAug 27, 2025
  If the spray from your SCIEX Laboratory Equipment is not uniform, the electrode might be blocked. Clean or replace the electrode.
K
Kevin JonesAug 27, 2025
How to resolve ion source fault on SCIEX ZenoTOF 7600 Laboratory Equipment?
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  Todd WallerAug 27, 2025
  If the control software reports that the mass spectrometer is in Fault status because of the ion source, check the following: 1. Confirm the fault in the Status panel of the device details page. 2. Verify that the probe is installed. If not, install it. 3. If the probe is already installed, remove and then reinstall it, ensuring the retaining ring is securely tightened.
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Stephanie SimpsonAug 25, 2025
What to do if my SCIEX ZenoTOF 7600 mass spectrometer is taking too long to pump down?
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  Amy JonesAug 26, 2025
  If your SCIEX Laboratory Equipment mass spectrometer is taking an excessive amount of time to pump down, consider the following: 1. The turbo pump controller might be defective; replacement may be necessary. 2. The orifice plate may not be sealed properly. To address this: * Press and hold the orifice plate in place to seal it. * If it still doesn't seal, remove and reinstall it. * If proper sealing cannot be achieved, replace the orifice plate.
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John PinedaAug 23, 2025
How to fix high vacuum pressure fault in SCIEX ZenoTOF 7600 Laboratory Equipment?
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  Shawn PetersAug 25, 2025
  A system fault due to high vacuum pressure in your SCIEX Laboratory Equipment can be addressed by checking the following: * **Oil-sealed roughing pump:** Inspect the oil level. If it's low, contact a local QMP or an FSE to add oil. * **Leaks:** Inspect and repair any leaks in the system. * **Orifice plate:** Ensure the correct orifice plate is installed.

SCIEX ZenoTOF 7600 Specifications

General

Mass Analyzer	Time-of-Flight (TOF)
Mass Accuracy	< 1 ppm
Ion Source	Turbo V ion source
MS/MS	Yes, with Zeno trap
Power Requirements	50/60 Hz
Mass Range	up to m/z 40, 000

Summary

Operational Precautions and Limitations

General Safety Information

General safety guidelines and warnings for system operation.

Regulatory Compliance

Lists the regulatory standards and compliance information for the system.

Electrical Precautions

Safety precautions related to electrical hazards and system connections.

Chemical Precautions

Safety measures for handling chemicals and hazardous materials.

Ventilation Precautions

Safety measures for system ventilation and exhaust.

Physical Precautions

Precautions related to physical handling and hazards.

Environmental Precautions

Guidelines for environmental safety and waste disposal.

Qualified Personnel

Specifies requirements for personnel performing installation and servicing.

Equipment Use and Modification

Guidelines for proper equipment usage and modifications.

Principles of Operation

System Overview

Provides a general overview of the ZenoTOF 7600 system components.

Hardware Overview

Details the physical components and their locations on the system.

Theory of Operation

Explains the mass spectrometry principles and ZenoTOF technology.

Operating Instructions — Hardware

Start Up the System

Step-by-step guide for powering on and preparing the system.

Shut Down and Vent the System

Procedures for safely shutting down and venting the system.

Diverter Valve

Information on the diverter valve and its plumbing configurations.

Calibrant Delivery System

Details the calibrant delivery system and its functions.

Operating Instructions — User Workflows

Analyst

Tasks and workflows for the Analyst user role.

Method Developer

Tasks and workflows for the Method Developer user role.

Administrator

Tasks and workflows for the Administrator user role.

Reviewer

Tasks and workflows for the Reviewer user role.

Service and Maintenance Information

Recommended Maintenance Schedule

Provides a schedule for routine cleaning and maintenance tasks.

Clean the Surfaces

Instructions for cleaning the external surfaces of the mass spectrometer.

Clean the Front-End

Procedure for cleaning the front-end components of the mass spectrometer.

Cleaning Best Practices

Tips and best practices for effective cleaning procedures.

Move the Mass Spectrometer

Detailed steps for safely moving the mass spectrometer.

Replace the CDS Bottle Intake Filters

Procedure for replacing the intake filters for the CDS bottle.

Inspect the Roughing Pump Oil Level (Oil-Sealed Roughing Pump)

How to check the oil level in the oil-sealed roughing pump.

Recommended Calibration Ions

APCI Calibration Ions

Lists recommended calibration ions for APCI mode.

ESI Calibration Ions

Lists recommended calibration ions for ESI mode.

Exact Masses and Chemical Formulas

Reserpine

Exact masses and chemical formulas for Reserpine.

Peptide ALILTLVS

Exact masses and chemical formulas for Peptide ALILTLVS.

Contact Us

Customer Training

Contact information for customer training programs.

Online Learning Center

Information about the online learning resources.

SCIEX Support

How to get technical support and assistance from SCIEX.

Documentation

Information on obtaining and accessing product documentation.

Related product manuals

SCIEX TripleTOF 5600 Plus

SCIEX ZenoTOF 7600 User Manual

Table of Contents