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Waters Quattro Premier XE User Manual

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Waters
Quattro Premier XE
Combined APPI and
APCI Source
Operators Guide
71500112702/Revision A
Copyright © Waters Corporation 2007
All rights reserved

Table of Contents

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Waters Quattro Premier XE Specifications

General IconGeneral
TypeTandem Quadrupole Mass Spectrometer
Ionization SourceElectrospray Ionization (ESI), Atmospheric Pressure Chemical Ionization (APCI)
SoftwareMassLynx
PolarityPositive and Negative
Polarity Switching speed20 ms
Data Acquisition RateUp to 10, 000 amu/sec
Scan ModesFull Scan, Precursor Ion Scan, Neutral Loss Scan, MRM
Scan SpeedUp to 10, 000 amu/sec
Mass Accuracy0.1 Da
Weight150 kg
ResolutionUnit mass resolution (0.7 ± 0.1 Da at half height)

Summary

Considerations specific to the Quattro Premier XE Combined APPI and APCI Source

Solvent leakage hazard

Discusses solvent leakage hazards and O-ring maintenance for the source exhaust system.

Safety advisories

Operating this instrument

Symbols

Explains common symbols used in the documentation and on the instrument.

Intended use

Describes the purpose and applications of the Quattro Premier XE Combined APPI and APCI Source.

Calibrating

Provides guidance on calibrating LC systems and mass spectrometers.

APPI, APCI, and Dual APPI/APCI Modes

APPI mode

Details the operation and configuration of the APPI ionization mode.

APCI mode

Details the operation and configuration of the APCI ionization mode.

Dual APPI/APCI mode

Explains the dual APPI/APCI mode for rapid switching between ionization methods.

The Combined APPI/APCI Source

Combined APPI/APCI Source Components

Describes the components of the combined APPI/APCI source.

Installing the Combined APPI/APCI Source

Provides instructions for installing the combined APPI/APCI source.

Removing the Combined APPI/APCI Source

Provides instructions for removing the combined APPI/APCI source.

Operating Procedures for APPI, APCI, and Dual Modes

Operating in APPI mode

Detailed instructions for preparing and operating the instrument in APPI mode.

Operating in APCI mode

Detailed instructions for preparing and operating the instrument in APCI mode.

Operating in Dual APPI/APCI mode

Detailed instructions for preparing and operating the instrument in dual APPI/APCI mode.

Maintenance Procedures

General Maintenance Information

Refers to the main instrument operator's guide for general maintenance details.

Maintenance Schedule

Outlines periodic maintenance tasks and their recommended frequencies for optimal performance.

Safety and Handling During Maintenance

Provides essential safety precautions and handling guidelines for maintenance procedures.

Removing O-rings and Seals

Details the procedure for safely removing O-rings and seals using the provided kit.

Changing the UV Lamp Bulb

Step-by-step guide for replacing the UV lamp bulb in the APPI lamp drive assembly.

Cleaning the Lamp Window

Instructions for cleaning the magnesium fluoride lamp window to maintain APPI performance.

Replacing APPI Lamp Drive Assembly O-rings

Comprehensive guide for replacing all O-rings within the APPI lamp drive assembly.

Safety Advisories

Warning Symbols Explained

Explains various warning symbols and their meanings to alert users to potential hazards.

Caution Symbol Meaning

Describes the caution symbol and its implications for instrument or sample integrity.

General Warnings for Waters Instruments

Lists general warnings applicable across all Waters instruments, covering various risks and precautions.

Electrical and Handling Symbols

Details electrical symbols and handling symbols used on instruments and packaging.

Materials of Construction and Compliant Solvents

Preventing Contamination

Provides guidance on preventing contamination within the instrument system.

Instrument Components Exposed to Solvents

Lists instrument components and their materials that may be exposed to solvents.

Solvents for Mobile Phase Preparation

Lists common ingredients used for preparing mobile phases in reverse-phase LC/MS.

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