Name: Waters Xevo G2 QTof
Brand: Waters
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Waters Xevo G2 QTof

Operator’s Overview and Maintenance Guide

Revision B

Waters Xevo G2 Qtof Overview19
Waters Xevo G2 Qtof20
ACQUITY and Nanoacquity Xevo G2 Qtof UPLC/MS Systems21
Software and Data System24
Electrospray Ionization (ESI)25
Atmospheric Pressure Chemical Ionization (APCI)26
Combined Electrospray and Atmospheric Pressure Chemical Ionization (Esci)27
Combined APPI/APCI Source29
Intellistart Fluidics System Physical Layout30
System Operation31
Ion Optics32
Leak Sensors33
Preparing the Mass Spectrometer for Operation35
Starting the Mass Spectrometer36
Verifying the Instrument's State of Readiness37
Flow Rates for the Xevo G2 Qtof System38
Adjusting the Solvent Delivery Tube Positions41
Purging the Pump42
Emergency Shutdown of the Mass Spectrometer43
Configuring the Lockspray Source45
Configuring the Lockspray Source46
Removing the ESI Probe50
Installing the Small-Bore Capillary Option51
Configuring for APCI Mode57
Removing the APCI Probe61
Configuring for Esci Mode62
Configuring the Nanolockspray Source63
Overview of the Nanolockspray Source64
Sample Sprayer65
Nanoflow Gas Supply66
Source Type Selection67
Advancing and Retracting the Sprayer Platform68
Adjusting the Sprayer Tip Position69
Setting up the Camera70
Optional Glass Capillary Sprayer71
Installing the Glass Capillary Sprayer72
Fitting and Loading the Glass Capillary73
Maintenance Procedures77
Maintenance Schedule79
Spare Parts80
Troubleshooting with Connections INSIGHT81
Safety and Handling82
Preparing the Instrument for Working on the Source83
Fitting the Source Enclosure to the Instrument86
Installing and Removing the Corona Pin87
Removing the Corona Pin from the Source89
Operating the Source Isolation Valve90
Removing O-Rings and Seals93
Emptying the Nitrogen Exhaust Trap Bottle94
Inspecting the Varian Roughing Pump Oil Level96
Adding Oil to the Varian Roughing Pump97
Replacing the Varian Roughing Pump's Oil and Oil Mist Filter99
Replacing the Oil Mist Filter100
To Fill the Pump with Oil102
Cleaning the Source Components104
Cleaning the Sampling Cone Assembly105
Disassembling the Sampling Cone Assembly107
Cleaning the Sample Cone and Cone Gas Nozzle110
Assembling the Sampling Cone Assembly112
Cleaning the Extraction Cone114
Removing the Extraction Cone from the Ion Block117
Cleaning the Extraction Cone118
Fitting the Extraction Cone to the Ion Block120
Fitting the Ion Block Assembly to the Source Assembly121
Cleaning the Ion Block Assembly122
Cleaning the Ion Block Components129
Assembling the Source Ion Block Assembly131
Cleaning the Source Hexapole Assembly133
Cleaning the Hexapole Assembly135
Fitting the Hexapole Assembly, PEEK Ion Block Support, and Ion Block Assembly to the Source Assembly137
Replacing the ESI Probe Tip and Gasket139
Fitting the ESI Probe Tip and Gasket141
Replacing the ESI Probe Sample Capillary142
Installing the New Capillary147
Cleaning the APCI Probe Tip151
Installing the New Capillary154
Replacing the Reference Probe Capillary (Lockspray Source)158
Installing the New Capillary160
Replacing the Reference Probe Capillary (Nanolockspray Source)161
Installing the New Tapertip and Capillary164
Cleaning or Replacing the Corona Pin166
Replacing the APCI Probe Heater167
Fitting the New APCI Probe Heater169
Replacing the Ion Block Source Heater170
Replacing the Lockspray Source's Assembly Seals174
Fitting the New Source Enclosure and Probe Adjuster Assembly Probe Seals176
Replacing the Mass Spectrometer's Air Filters178
Replacing the Air Filters on the Sides of the Instrument180
Replacing the Intellistart Fluidics Tubing182
Removing the Intellistart Fluidics Tubing183
Plumbing the Intellistart Fluidics Lock-Spray System184
Plumbing the Intellistart Fluidics Sample Delivery System192
A Safety Advisories199
Warning Symbols200
Specific Warnings201
Caution Symbol203
Warnings that Apply to All Waters Instruments204
Electrical and Handling Symbols209
Handling Symbols210
B External Connections211
Mass Spectrometer External Wiring and Vacuum Connections212
Connecting the Varian Oil-Filled Roughing Pump213
Making the Electrical Connections to the Varian Oil-Filled Roughing Pump216
Connecting the Edwards Oil-Free Roughing Pump217
Making the Electrical Connections to the Edwards Oil-Free Roughing Pump220
Connecting to the Collision Cell Gas Supply222
Connecting the Liquid Waste Line225
Connecting the EPC228
Connecting the Workstation (Systems with no ACQUITY LC)229
Connecting Ethernet Cables (Systems with ACQUITY LC)230
Signal Connections233
Connecting to the Electricity Source236
Installing the Camera Driver Software237
C Materials of Construction and Compatible Solvents239
Preventing Contamination240
Solvents Used to Prepare Mobile Phases241
Index243

Brand	Waters
Model	Xevo G2 QTof
Category	Laboratory Equipment
Language	English

Waters Xevo G2 QTof Service Manual

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