Name: Waters Xevo TQ-S
Brand: Waters
Rating: 5 (1 reviews)

To Next Page

Waters Xevo TQ-S

Mass Spectrometry

System

Operator’s Overview and Maintenance Guide

715002212 / Revision C

General Information3
Trademarks3
Contacting Waters5
Safety Considerations6
Considerations Specific to the Xevo TQ-S System6
FCC Radiation Emissions Notice10
Canada Spectrum Management Emissions Notice10
Safety Hazard Symbol Notice10
Equipment Misuse Notice10
Safety Advisories10
Operating this Instrument11
Applicable Symbols11
Audience and Purpose13
Intended Use of the Xevo TQ-S13
Calibrating13
Quality Control14
ISM Classification14
ISM Classification: ISM Group 1 Class a14
EC Authorized Representative15
Table of Contents17
Waters Xevo TQ-S Overview25
Waters Xevo TQ-S26
ACQUITY UPLC/MS Xevo TQ-S Systems28
Non-ACQUITY Devices for Use with the Xevo TQ-S30
Software and Data System31
Ionization Techniques and Source Probes32
Esi32
Esci32
Apci32
Dual-Mode APPI/APCI Source33
Low-Flow ESI Probe33
Nanoflow ESI Source33
Atmospheric Solids Analysis Probe34
Apgc34
TRIZAIC UPLC Source34
Ionkey Source34
Intellistart Fluidics System35
Overview35
System Components36
System Operation36
Ion Optics36
MS Operating Modes37
MS/MS Operating Modes38
Product (Daughter) Ion Mode39
Precursor (Parent) Ion Mode40
MRM Mode40
Constant Neutral Loss Mode41
Scanwave Daughter Scan Mode42
Leak Sensors42
Vacuum System43
Rear Panel43
Preparing the Mass Spectrometer for Operation45
Starting the Mass Spectrometer46
Verifying the Instrument's State of Readiness48
Monitoring the Mass Spectrometer Leds48
Tuning and Calibration Information49
Running the Mass Spectrometer at High Flow Rates50
Preparing the Intellistart Fluidics System51
Installing the Reservoir Bottles51
Adjusting the Solvent Delivery Tube Positions53
Purging the Infusion Pump54
Rebooting the Mass Spectrometer55
Leaving the Mass Spectrometer Ready for Operation56
Emergency Shutdown of the Mass Spectrometer56
Changing the Mode of Operation57
ESI Mode57
Installing the ESI Probe58
Removing the ESI Probe62
Esci Mode62
Optimizing the ESI Probe for Esci Operation63
APCI Mode63
Installing the Ionsabre II Probe64
Removing the Ionsabre II Probe67
Combined APPI/APCI Source67
APPI Operation67
APCI Operation68
Dual-Mode Operation69
The Combined APPI/APCI Source Components70
Installing the Combined APPI/APCI Source72
Nanoflow ESI Source74
Installing the Nanoflow Source76
Fitting a Borosilicate Glass Capillary (Nanovial)78
Positioning the Borosilicate Glass Capillary Tip81
Restarting a Stalled Borosilicate Glass Capillary Electrospray82
Ionkey Source82
Installing the Ionkey Source83
Installing Ionkey Source Software88
Installing the Camera in the Ionkey Source89
Removing an Ionkey Source89
Maintenance Procedures91
Maintenance Schedule92
Spare Parts95
Troubleshooting with Connections INSIGHT96
Safety and Handling97
Preparing the Instrument for Working on the Source98
Removing and Refitting the Source Enclosure100
Removing the Source Enclosure from the Instrument100
Fitting the Source Enclosure to the Instrument102
Installing and Removing the Corona Pin102
Installing the Corona Pin in the Source103
Removing the Corona Pin from the Source105
Operating the Source Isolation Valve107
Removing O-Rings and Seals110
Cleaning the Instrument Case111
Emptying the Nitrogen Exhaust Trap Bottle111
Maintaining the Oerlikon Leybold Oil-Filled Roughing Pumps113
Gas Ballasting the Oerlikon Leybold Roughing Pumps115
Inspecting the Roughing Pump Oil Levels116
Adding Oil to a Roughing Pump116
Replacing the Roughing Pumps' Oil and Oil Demister Elements119
Gas Ballasting the Edwards Xds35I Oil-Free Roughing Pump127
Cleaning the Source Components128
Cleaning the Sampling Cone Assembly129
Removing the Sampling Cone Assembly from the Source129
Disassembling the Sampling Cone Assembly131
Cleaning the Sample Cone and Cone Gas Nozzle134
Assembling the Sampling Cone Assembly136
Fitting the Sampling Cone Assembly to the Source137
Cleaning the Ion Block Assembly139
Removing the Ion Block Assembly from the Source Assembly139
Disassembling the Source Ion Block Assembly141
Cleaning the Ion Block Components147
Assembling the Source Ion Block Assembly149
Fitting the Ion Block Assembly to the Source Assembly150
Cleaning the Stepwave Ion Guide Assembly152
Handling the Stepwave Ion Guide Assembly152
Removing the Ion Block Support from the Source Assembly152
Removing the Stepwave Assembly from the Source Assembly154
Disassembling the Stepwave Ion Guide Assembly158
Cleaning the Stepwave Ion Guide Assembly161
Assembling the Stepwave Ion Guide Assembly165
Fitting the Stepwave Assembly to the Source Assembly167
Fitting the Ion Block Support to the Source170
Replacing the ESI Probe Tip and Gasket171
Removing the ESI Probe Tip and Gasket171
Fitting the ESI Probe Tip and Gasket174
Replacing the ESI Probe Sample Capillary175
Removing the Existing Capillary175
Installing the New Capillary180
Cleaning the Ionsabre II Probe Tip183
Replacing the Ionsabre II Probe Sample Capillary184
Removing the Existing Capillary184
Installing the New Capillary187
Cleaning or Replacing the Corona Pin190
Replacing the Ionsabre II Probe Heater191
Removing the Ionsabre II Probe Heater191
Fitting the New Ionsabre II Probe Heater193
Replacing the Ion Block Source Heater195
Replacing the Source Assembly Seals199
Removing the Probe Adjuster Assembly Probe and Source Enclosure Seals199
Fitting the New Source Enclosure and Probe Adjuster Assembly Probe Seals201
Replacing the Air Filter203
APPI/APCI Source-Changing the UV Lamp Bulb205
APPI/APCI Source-Cleaning the Lamp Window207
APPI/APCI Source-Replacing the APPI Lamp Drive Seals208
Removing the APPI Lamp Drive Assembly Seals208
Fitting the New APPI Lamp Drive Assembly O-Rings213
Replacing the Ionkey Source Fluid Lines216
Removing a Fluid Line217
Installing a Fluid Line219
Cleaning the Ionkey Source and Connectors220
A Safety Advisories223
Warning Symbols224
Specific Warnings225
Caution Advisory228
Warnings that Apply to All Waters Instruments and Devices229
Warnings that Address the Replacing of Fuses234
Electrical and Handling Symbols236
Electrical Symbols236
Handling Symbols237
B External Connections239
External Wiring and Vacuum Connections240
Connecting the Oerlikon Leybold Oil-Filled Roughing Pumps241
Connecting the Edwards Oil-Free Roughing Pumps248
Making the Roughing Pump Connections to the Xevo TQ-S254
Connecting to the Nitrogen Supply255
Connecting to the Collision Cell Gas Supply256
Connecting the Nitrogen Exhaust Line257
Connecting the Liquid Waste Line260
Connecting the Workstation262
Connecting Ethernet Cables for an LC/MS System263
Input/Output Signal Connectors263
Making Signal Connections266
Connecting to the Electricity Source269
C Materials of Construction and Compatible Solvents271
Preventing Contamination272
Items Exposed to Solvent272
Solvents Used to Prepare Mobile Phases273
D Plumbing the Intellistart Fluidics System275
Preventing Contamination275
Plumbing Schematic276
Ionkey and Trizaic Source Plumbing277
Tubing Specifications278

Brand	Waters
Model	Xevo TQ-S
Category	Laboratory Equipment
Language	English

Waters Xevo TQ-S User Manual

Table of Contents

Other manuals for Waters Xevo TQ-S

Questions and Answers:

Waters Xevo TQ-S Specifications

Related product manuals