FagronLab BASIC - Mixing Parameters

FagronLab™ BASIC – User Manual | 24
FagronLab™ BASIC
Mixing parameters
Pre-grinding
The pre-grinding process serves to wetten solids in the preparation of suspension with an active substance content < 2 %, allowing
a homogeneous distribution of active substances in an ointment foundation.
As an example, the incorporation of corticoids, antibiotics, fungicides or hormones in an ointment foundation. In order to ensure a
homogenous distribution, we recommend using the standard mixing blade.
First, load approximately 30 % of the foundation ground-covering in the jar and cover the micronized active substances with
foundation. The active substances have to be covered in the foundation in order to avoid powder residue sticking on the blade.
The jar bottom should be pushed up as far as possible to prevent incorporating air.
Please inspect the preparation for agglomerates or qualitative abnormalities after the pre-grinding process is completed. If
required, the pre-grinding process may be repeated.
Suspension < 2 %
After finalizing the pre-grinding process both the remaining foundation and all active substances will be weighed in.
To incorporate air as little as possible push the movable jar bottom up until resistance is felt.
Further processing of the compound should be prepared by using the parameters "Suspension < 2 %".
Pre-grinding - Level 4 (1200 rpm)
Jar size 15 - 30 ml 50 - 100 ml 200 ml 300 - 500 ml
Time (min.) 2:30 3:30 5:00 10:00
Stirrer SMB SMB SMB SMB
Level 7 (1900 rpm)
Jar size 15 - 30 ml 50 - 100 ml 200 ml 300 - 500 ml
Time (min.) 1:30 2:00 3:30 4:40
Stirrer SMB SMB SMB SMB
Tab: Mixing parameter pre-grinding
Tab: Mixing parameter suspension < 2 %