FagronLab BASIC - Requirements for Components of a Formulation

FagronLab™ BASIC – User Manual | 28
FagronLab™ BASIC
Soft in soft
With the mixing parameters "Soft in Soft" semisolid substances from low-viscous to pasty can be mixed together.
As an example, combining two foundations.
To ensure a homogeneity we recommend applying disp. blades for low-viscous and the standard mixing blades for high-viscous
foundations.
Specialties
With the mixing parameters "Specialities" surface-active or sensitive active substances or force sensitive foundations can be
processed.
As an example, metronidazole, chlorhexidine gluconate, Linola®.
Therefore with suspension ointments < 2 % first use the "pre-grinding" parameters and for the main mixing process the mixing
parameters "specialties".
Level 7 (1900 rpm)
Jar size 15 - 30 ml 50 - 100 ml 200 ml 300 - 500 ml
Time (min.) 1:40 2:10 4:10 5:10
Stirrer Disp. Blade or SMB Disp. Blade or SMB Disp. Blade or SMB SMB
Level 4 (1200 rpm)
Jar size 15 - 30 ml 50 - 100 ml 200 ml 300 - 500 ml
Time (min.) 5:00 7:30 12:55 17:00
Stirrer Disp. Blade or SMB Disp. Blade or SMB Disp. Blade or SMB SMB
Tab: Mixing parameter soft in soft
Tab: Mixing parameter specialties
Requirements for the components of a formulation
Powder
Generally, powders should be used as microfine and micronized substances.
In order to ensure better wetting of powders in aqueous compounds, micronized substances should be added after any liquid
components or covered with foundation.
For a solids content less than 2 %, we recommend applying the pre-grinding process together with approx. 30 % of the ointment
foundation (review pre-grinding).