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Table of Contents
1. Introduction ________________________________________________________ 4
2. Warnings __________________________________________________________ 5
2.1 Hazard Icons ______________________________________________________________ 5
2.2 Hazard Level ______________________________________________________________ 6
2.3 Safety Messages ___________________________________________________________ 7
3. Overview _________________________________________________________ 10
3.1 iCELLis 500+ Single-Use Fixed-Bed Bioreactor ___________________________________ 10
3.2 iCELLis 500+ Control System _________________________________________________ 11
4. iCELLis 500+ Control System Environment Requirements ________________ 15
5. Unpacking and Installing the iCELLis 500+ Control System _______________ 16
5.1 Unpacking ________________________________________________________________ 16
5.2 Moving and Positioning the iCELLis 500+ Control System __________________________ 18
5.2.1 Unlocking Load Cells ______________________________________________________________ 18
5.2.2 Locking in Position and Levelling the System ___________________________________________ 19
5.3 Fitting High Speed Pumps on the iCELLis 500+ Control System ______________________ 20
5.4 Fitting the Base Scale on the iCELLis 500+ Control Aystem _________________________ 21
5.5 Fitting the Tubing Holders on the iCELLis 500+ Control System ______________________ 22
5.6 Fitting Communication and Sensor Cables to the iCELLis 500+ Control System _________ 23
5.6.1 Connecting the Double Jacket Pressure Sensor Cable: ___________________________________ 23
5.6.2 Connecting the Bioreactor Pressure Sensor Cable: ______________________________________ 23
5.6.3 Connecting the T1 and T2 Temperature Probes: ________________________________________ 25
5.6.4 Connecting Optical Fibers for pH and DO: _____________________________________________ 26
5.6.6 Connecting the Filter Heater: ________________________________________________________ 28
5.6.7 Connecting the Bag Pre-Heater _____________________________________________________ 30
5.7 Installation of the Temperature Control Unit (TCU) ________________________________ 31
5.8 iCELLis 500+ Control System Electrical Installation ________________________________ 35
5.8.1 Electrical Power Requirements ______________________________________________________ 35
5.8.2 Power Connection and Powering ON _________________________________________________ 35
5.9 Fitting the Gas Supplies to the iCELLis 500+ Control System ________________________ 36
6. iCELLis 500+ Control System Specifications ____________________________ 38
6.1 General Specifications ______________________________________________________ 38
6.2 Sensors and Actuators Specifications __________________________________________ 41
6.3 Temperature Control Unit Specifications ________________________________________ 42
7. Cleaning __________________________________________________________ 43
8. Maintenance ______________________________________________________ 44
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