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Thermo Scientific thermoscientific Vanquish UHPLC System User Manual

Thermo Scientific thermoscientific Vanquish UHPLC System
148 pages
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thermo
scientific
Vanquish
UHPLC System
Operating Manual
4820.3601-EN Revision 4.0 December 2019

Table of Contents

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Thermo Scientific thermoscientific Vanquish UHPLC System Specifications

General IconGeneral
BrandThermo Scientific
Modelthermoscientific Vanquish UHPLC System
CategoryLaboratory Equipment
LanguageEnglish

Summary

Using this Manual

About this Manual

Provides instructions for installation, setup, operation, maintenance, and troubleshooting of the system.

Conventions

Describes conventions used throughout the manual, including safety messages and special notices.

Safety

Safety Symbols and Signal Words

Explains safety symbols and signal words used in the manual to convey hazards.

Intended Use

Defines the system's intended purpose for analyzing compound mixtures in sample solutions.

Safety Precautions

Outlines essential safety precautions for system installation, operation, and maintenance.

General Safety Information

General safety guidelines applicable to all phases of system use and handling.

Qualification of the Personnel

Specifies the necessary qualifications for personnel installing and operating the system.

Personal Protective Equipment

Details required personal protective equipment for safe handling of hazardous substances.

General Residual Hazards

Highlights potential residual hazards like hazardous substances and biohazards.

In Case of Emergency

Provides critical instructions for actions to take in emergency situations.

Solvent and Additive Information

Offers recommendations and guidelines for using solvents and additives.

System Overview

System Description (Standard Configuration)

Describes the standard configurations of Vanquish systems and their modules.

Solvent Rack

Details the solvent rack's function for storing solvent reservoirs securely.

System Base

Explains the system base as a mandatory part providing power control and storage.

Operation

Introduces system operation, primarily via Chromeleon software.

Unpacking

Unpacking

Provides step-by-step instructions for unpacking the solvent rack and system base.

Scope of Delivery

Lists the items included in the system delivery.

Installation

Safety Guidelines for Installation

Emphasizes safety guidelines to be observed during system installation.

Installing the System

Outlines the general steps for installing the Vanquish system.

Site Requirements

Specifies requirements for the installation site to ensure optimal performance.

Workbench

Defines workbench requirements for placing and supporting the Vanquish system.

Power Considerations

Highlights important considerations regarding power supply and connections.

Power Cord

Provides safety warnings and guidelines for using power cords.

Condensation

Warns about condensation damage to electronics and how to avoid it.

Operating Conditions

Specifies environmental conditions like temperature and humidity for operation.

Setting Up the Hardware

Details how to set up system hardware, including connectors and cables.

System Stack Setup

Provides instructions for physically assembling the system modules.

Signal Cable Connections

Explains how to connect signal cables for system communication.

Power Connections

Guides on how to connect system modules to the power source.

Setting Up the Flow Connections

Provides an overview and guidelines for setting up fluid connections.

Connecting Fittings, Capillaries, and Tubing

Details how to connect and handle capillaries, fittings, and tubing.

Connecting the Waste Lines

Explains the process of connecting waste lines for proper disposal.

Turning On the System

Provides step-by-step instructions for powering on the system.

Setting Up the System in the Software

Guides on configuring the Vanquish system using Chromeleon software.

Flushing the System

Describes how to flush the system after installation.

Operation

Safety Guidelines for Operation

Highlights safety guidelines crucial for operating the chromatography system.

Preparing the System for Operation

Details additional steps required before system operation and sample analysis.

Use of Solvents and Additives

Provides guidelines for optimal system performance using solvents and additives.

Operating the System from the Software

Explains how to operate the Vanquish system using Chromeleon software.

Starting the Instrument Controller and Client

Instructions for starting the Chromeleon Instrument Controller and client.

Running Automated Sample Analysis

Guides on creating and running sequences for automated sample analysis.

Shutting Down the System

Provides guidelines for short-term and long-term system shutdown.

Maintenance and Service

Safety Guidelines for Maintenance and Service

Highlights safety guidelines for performing maintenance and service procedures.

General Rules for Maintenance and Service

Outlines rules and recommendations for successful maintenance procedures.

Routine and Preventive Maintenance

Details routine and preventive maintenance procedures for system upkeep.

Maintenance Plan

Suggests a regular maintenance schedule based on system usage.

Cleaning or Decontaminating the System

Provides procedures for cleaning and decontaminating system components.

Transporting or Shipping the System

Explains procedures for safely transporting or shipping the system.

Troubleshooting

General Information about Troubleshooting

Provides general information and tips for resolving operating issues.

System Troubleshooting

Guides on identifying and resolving issues related to system modules and connections.

Peak Shape

Troubleshooting guide for issues related to peak shape, such as tailing or broadening.

Ghost Peaks, Negative Peaks and Spikes

Addresses troubleshooting for ghost peaks, negative peaks, and spikes in chromatograms.

Peak Area Precision

Troubleshooting for issues affecting peak area precision, including carry-over.

Flow

Troubleshooting guide for problems related to system flow, including no flow and fluctuations.

Pressure

Troubleshooting for pressure-related issues like pulsation or high/low backpressure.

Retention Time Variation

Addresses troubleshooting for variations in retention times.

Baseline

Troubleshooting for baseline drift, fluctuations, and noise.

Temperature Control

Troubleshooting for issues with column compartment and pre-heater temperature.

Power and Communication

Troubleshooting for power issues and communication problems with modules.

System Diagnostics

Information on running diagnostic tests for system modules.

Specifications

System Specifications

Lists the physical conditions and operating specifications of the Vanquish system.

Solvent Rack and System Base Specifications

Provides physical specifications for the solvent rack and system base.

Accessories, Consumables and Replacement Parts

General Information

General information about using authorized replacement parts and components.

Ship Kit

Lists the items included in the system's ship kit.

Optional Accessories

Lists optional accessories available for the Vanquish system.

Consumables and Replacement Parts

Details consumables and replacement parts, including capillaries and tubing.

Capillaries and Tubing

Lists specific part numbers for capillaries and tubing.

Solvents and Wash Systems

Provides part numbers for solvent reservoirs and related components.

Appendix

Compliance Information

Provides information on compliance with domestic and international regulations.

Declarations of Conformity

Details CE declaration and RoHS compliance of the product.

WEEE Compliance

Information regarding compliance with the Waste Electrical & Electronic Equipment Directive.

FCC Compliance

Details FCC compliance for the device operating in commercial environments.

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