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TSQ 8000 Evo
Thermo Scientific TSQ 8000 Evo User Manual
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TSQ 8000 Evo
Mass Spectrometer
User Guide
1R120586-0002
Revision C
December 2015
2
Table of Contents
Default Chapter
3
Default Chapter
3
Table of Contents
3
About Your System
9
Preface
9
Related Documentation
10
System Requirements
11
Safety and Special Notices
11
Safety Symbols and Signal Words
11
Hydrogen Safety Precautions
13
Using Hydrogen with a GC-MS/MS System
14
Hydrogen Safety Screws on the Mass Spectrometer
14
Hydrogen Connection Guidelines
15
Purchasing Hydrogen
16
Properly Storing Hydrogen
17
Hydrogen Safety Codes, Standards and References
19
Hazardous Substances Precautions
20
Biological Hazard Warning Note
20
Venting Toxic Gases
21
Contacting Us
21
Confirming Your Instrument Is Working
23
Checking Power to the System
23
Chapter 1 Introduction
23
Verifying the Carrier Gas Flow Rate
24
Checking Your Carrier Gas Tank Pressure
26
Verify Collision Gas Tank Pressure
26
Checking the Vacuum and Temperature
26
Using the Lights on the Instrument
27
Configuring Your Instrument
28
Checking System Vacuum on the Dashboard
28
Cleaning the Exterior of Your Instrument
28
Setting the Pressure Units
31
Setting the Remote Start
32
Enabling Method Portability
32
Setting up the Network
33
Setting the Maintenance Intervals
33
Main Instrument Configuration Window
34
GC Handshaking Parameter Configuration
35
Determining the Column Type
37
Chapter 2 Changing the Column
37
Replacing the Factory Installed Column
38
Connecting the Column to the Transfer Line
43
Transfer Line Nut and Graphite Vespel Ferrule Orientation
44
Lining up the Column in the Column Measuring Tool
45
Positioning the Septum
45
Pulling the Column Back from the Spring Loaded Transfer Line Nut
45
Positioning the Column in the Transfer Line
47
Transfer Line Nut and Siltite Ferrule Orientation
48
Pulling the Column Back from the Transfer Line Nut
50
Inserting the Column into the Transfer Line
51
Accessing Auto Tune
53
Chapter 3 Tuning
53
Tuning the Mass Spectrometer
54
TSQ Series Dashboard
54
Tuning Categories
55
Tune Types
55
EI Standard Tune
55
EI Standard Quick Tune
56
EI SRM Tune
56
EI Tune Check
56
EI Target Tune/Ei Initial Tune
56
Fast Scan Tune
57
CI- Tune
57
CI+ Tune
57
Displaying a Report
58
Sample Tune Report
59
Tune Report Options
60
Printing a Tune Report
61
Updating Tunes for New RF Lens
62
Loading Tune Results
62
Opening Manual Tune on the TSQ Series Dashboard
63
Accessing Frequency Tune
63
Locating the Device Menu
64
Saving the New Ion Guide Frequency to the Instrument
64
Selecting the Correct Number of Spectra to Scan
65
Setting the Calibration Gas Level to EI
65
Checking the Mass Intensities
66
Creating a Method
67
Accessing the Method Editor
67
Chapter 4 Creating a Method
67
Method Editor Window
68
Creating an Autosampler Method
69
General GC Liquids Settings on the Triplus RSH Sampling System
70
GC Liquids Washes Settings
71
Creating a MS Instrument Method
72
Post-Injection
72
Pre-Injection
72
Rinse
72
TSQ Series Method Type Setup
73
General Acquisition: Setting Temperatures and Acquisition Threshold
74
Setting the CI Gas Ports
75
Acquisition-General CI Settings
76
For Acquisition-General Methods Only
76
Grouping SRM Scans
78
Accessing the Groups Pane
81
Determining Groups Total Scan Time
82
Acquisition-Timed Method Settings
84
Linking to an External File Using SIM Bridge
85
Setting the Source Language of Method Files Using Simbridge
85
Changing Method Headings in Simbridge
86
Viewing a Linked File in the Method Editor
86
Finding an Analyte in a Method
87
Accessing the Show Analysis Feature
88
Validating a Method
89
Choosing Display Options for Analytes
90
Acquisition-Timed Scan Settings
91
Acquisition-Timed Instrument Settings
95
Importing Methods
96
Creating a New Target Ion
97
Moving the Confirming Ion to the Compound Name
97
Adding a New Confirming Ion to a Target Ion
98
Locating the New Target Ion
98
Locating the New Confirming Ion
99
Moving the Confirming Ion to the Target Ion of Interest
99
Configuring the Tune Report Options
100
Creating a GC Method
100
GC Oven Settings
101
Configuring the Injector Port Settings on the GC
102
PTV Settings
104
Configuring the GC Run Table
105
Adding a GC Inlet or Detector to the Method Editor
106
Saving a Method
107
Validating and Troubleshooting Methods
107
To Decrease the Desired Scans Per Peak
108
Viewing the Analytes
108
To Reduce the Acquisition Windows
109
Validated Method
110
Chapter 5 Optimizing Your Method
111
Changing the Chromatographic Separation
111
Finding the Best Way to Make an Injection
112
Improving the Way You Prepare Samples
112
Changing the Dwell Time or Scan Rate
112
To Prioritize the Dwell Times of the Problem Analytes
112
Narrowing the Mass Range
113
Adjusting the Transfer Line and Ion Source Temperature
113
Optimizing an SRM Method
114
Optimizing an NCI Tune
114
To Optimize the CI Ion Volume Position Using Methane
117
Saving a New NCI Tune File
117
Modifying an Automatic Tune
118
Configuring General Tuning Parameters
118
Starting Tune File
119
Configuring the Ion Source Parameters
120
Electron Energy
121
Electron Lens Positive Voltage
121
Electron Lens Negative Voltage
121
Set Ion Source Temperature
122
Configuring Tuning Targets
122
Configuring the Detectors
123
Set Initial Detector Gain
123
Tune Detector
123
Adjust Detector Sensitivity
123
Setting Diagnostics
124
Selecting Data Report Options
124
Acquire Full-Scan Spectrum
124
Renaming a Tune Type
125
To Modify Advanced Tune Settings
126
Changing a Tune File Name
126
Tuning the Q1 Lenses
126
Repeller
127
Ion Guide Voltage
127
Ion Guide RF
127
Q1 Voltage
127
Step
128
Max Width
128
Threshold
128
On Error
128
Configuring Q1 Resolution
129
Tuning the Q3 Lenses
130
Q3 Voltage
130
Resolution
130
To Configure the Resolution of Your Tune
131
Configuring the Q3 Resolution
132
Tune High Scan Rate
132
Computer Settings
133
To Use the Power Save Feature
133
Chapter 6 Computer Settings
133
System Requirements
133
To Use the Virtual Memory Feature
134
Power Settings for the Computer
134
Virtual Memory Settings
134
To Confirm the Network Card Firewall Settings
135
Setting the Network Connections
135
Excluding the Xcalibur Directory from Virus Scan
136
Chapter 7 Troubleshooting
137
Diagnostics Checks
138
How to Know When Your System Needs Maintenance
139
Diagnostics and Corrective Actions
139
Common Contaminants
140
Investigating Baseline Issues
141
Drifting Baseline
141
Noisy Chromatographic Peaks
142
Investigating Peak Issues
143
Troubleshooting Peak Issues in Your Data
143
Broadening
143
Fronting
143
Tailing
144
Ghost Peaks
145
Missing Peaks
145
Investigating Results Issues
146
Low Reproducibility of Peaks Area
146
Poor Sensitivity
147
Retention Times
147
Index
149
Other manuals for Thermo Scientific TSQ 8000 Evo
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Preinstallation Manual
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Thermo Scientific TSQ 8000 Evo Specifications
General
Brand
Thermo Scientific
Model
TSQ 8000 Evo
Category
Laboratory Equipment
Language
English
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