Thermo Scientific TSQ 8000 Evo User Manual

TSQ 8000 Evo
Mass Spectrometer
User Guide
1R120586-0002 Revision C December 2015

Thermo Scientific TSQ 8000 Evo Specifications

General

Type	Triple Quadrupole Mass Spectrometer
Polarity Switching	Yes
Weight	Approx. 120 kg
Ion Source	Electrospray Ionization (ESI) and Atmospheric Pressure Chemical Ionization (APCI)
Resolution	Unit resolution (0.7 FWHM)
Data Acquisition	Product Ion Scan, Precursor Ion Scan, Neutral Loss Scan
Power Requirements	100-240 VAC, 50/60 Hz
Operating Temperature	15-30 °C (59-86 °F)
Operating Humidity	20-80% non-condensing
Scan Speed	Up to 20, 000 Da/sec

Summary

Chapter 1 Introduction

Confirming Your Instrument is Working

Steps to verify the TSQ 8000 Evo system is operating correctly.

Configuring Your Instrument

Instructions for configuring the TSQ 8000 Evo system.

Chapter 2 Changing the Column

Replacing the Factory Installed Column

Step-by-step procedure for replacing the installed GC column.

Connecting the Column to the Transfer Line

Chapter 3 Tuning

Accessing Auto Tune

Tuning the Mass Spectrometer

Procedures for tuning the mass spectrometer parameters.

Chapter 4 Creating a Method

Accessing the Method Editor

Creating an Autosampler Method

Creating a MS Instrument Method

Creating a GC Method

Validating and Troubleshooting Methods

Procedures for validating and troubleshooting created methods.

Chapter 5 Optimizing Your Method

Changing the Chromatographic Separation

Changing the Dwell Time or Scan Rate

Adjusting the Transfer Line and Ion Source Temperature

Optimizing an SRM Method

Modifying an Automatic Tune

Chapter 7 Troubleshooting

Diagnostics Checks

Steps to perform diagnostics and interpret results.

How to Know When Your System Needs Maintenance

Investigating Baseline Issues

Identifying causes and remedies for baseline problems.

Investigating Peak Issues

Identifying causes and remedies for peak shape problems.

Investigating Results Issues

Identifying causes and remedies for data result issues.