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Thermo Scientific TSQ Fortis User Manual

Thermo Scientific TSQ Fortis
176 pages
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TSQ Series II
TSQ Altis, TSQ Quantis,
and TSQ Fortis
Hardware Manual
80111-97047 Revision A June 2018

Table of Contents

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Thermo Scientific TSQ Fortis Specifications

General IconGeneral
BrandThermo Scientific
ModelTSQ Fortis
CategoryLaboratory Equipment
LanguageEnglish

Summary

Chapter 2 Principles of Operation

Overview of the MS System

Explains the MS system composition including API source, ion optics, mass analyzer, and detection.

Overview of Ion Optics and Mass Analyzer

Describes how ion optic assemblies and mass analyzer assemblies control ion paths.

Chapter 3 Vacuum System

Vacuum Pumps

Details the function of forepumps and turbomolecular pumps in the vacuum system.

Chapter 5 Atmospheric Source Interface

API Source Interface Overview

Introduces the components of the API source interface within the vacuum chamber.

Ion Transfer Tube

Explains the function of the ion transfer tube in desolvating and transferring ions.

RF and Exit Lens

Describes the RF and exit lenses' role in ion transmission and focusing.

Chapter 6 Ion Optics and Detector Components

MP00 Ion Optics

Details the MP00 RF lens and L0 lens for guiding ions.

MP0 Ion Optics and Beam Blocker

Explains MP0 ion optics and the beam blocker for transmitting and filtering ions.

Dual-Mode, Discrete-Dynode Ion Detection System

Describes the ion detection system including conversion dynode and electron multiplier.

Chapter 8 Using the MS Power Options

Turning the MS On

Provides steps to turn on the MS using the Tune window.

Placing the MS in Standby Mode

Guides on how to put the MS into standby mode for short-term inactivity.

Shutting Down the MS System in an Emergency

Details the emergency shutdown procedure using the main power switch.

Chapter 9 Shutting the MS System Down Completely

Shutting the MS Down Completely

Outlines the complete shutdown procedure for extended periods or maintenance.

Chapter 10 Restarting the MS System After a Shutdown

Restarting the Data System

Explains procedures for restarting the data system using Windows or power button.

Resetting the Mass Spectrometer

Describes how to reset the MS using the communication panel reset button.

Pumping the MS Down

Details the procedure for achieving sufficient vacuum after shutdown.

Chapter 12 Maintaining the MS on a Daily Basis

Before Operating the Mass Spectrometer

Outlines essential tasks to ensure the MS is ready for operation.

Finding and Fixing Air Leaks

Describes how to detect and resolve air leaks in the vacuum system.

Checking the Vacuum Pressure Levels

Explains how to check vacuum pressure readings in the Tune window.

After Operating the Mass Spectrometer

Lists tasks to perform after operating the MS to prevent downtime.

Flushing the Inlet Components

Provides steps for flushing inlet components with cleaning solutions.

Placing the System in Standby Mode

Guides on placing the MS in standby mode after daily maintenance.

Chapter 14 Connecting the Sample Flow to the Source

Connecting the Sample Flow to the H-ESI Source

Details the connection of sample flow to H-ESI or low-flow H-ESI sources.

Connecting the Sample Flow to the APCI Source

Explains how to connect sample flow to the APCI spray insert.

Chapter 15 Calibrating the MS

Preparing the Syringe Pump for Calibration

Guides on preparing the syringe pump for infusing calibration solution.

Calibrating and Tuning the MS

Outlines the procedure for successful MS calibration and tuning.

Chapter 16 Optimizing the Compound Signal

Optimizing Parameters in the Optimization Pane

Details how to optimize MS parameters in the Tune application's optimization pane.

Chapter 17 Scan Types

Selected Reaction Monitoring Scan Type

Details SRM scan type for monitoring specific precursor/product ion transitions.

Chapter 19 Acquiring Sample Data

Using Tune to Acquire Sample Data

Provides steps to acquire sample data using the Tune application.

Using the Xcalibur Data System to Acquire Sample Data

Details acquiring sample data using the Xcalibur data system.

Chapter 20 Maintenance Schedule and Supplies

Chapter 21 Maintaining the API Source and Replacing the H-ESI Needle

Chapter 22 Maintaining the RF Lens, Exit Lens, MP00 RF Lens, and Lens L0

Removing the RF Lens, Exit Lens, MP00 RF Lens, and Lens L0 (Altis/Quantis)

Provides steps for removing specific lenses for Altis/Quantis models.

Removing the Exit Lens, MP00, and Lens L0 (Fortis)

Details the procedure for removing lenses from the Fortis model.

Cleaning the RF Lens, Exit Lens, MP00, and Lens L0

Explains cleaning procedures for RF lens, exit lens, MP00, and L0 lens.

Chapter 23 Maintaining the API Source Interface

Removing the Ion Sweep Cone and the Ion Transfer Tube

Details removing ion sweep cone and ion transfer tube to clean blockages.

Cleaning the Ion Transfer Tube

Outlines cleaning procedures for the ion transfer tube.

Chapter 24 Maintaining the Forepumps and the Air Filter

Appendix A Using Basic Tune Functions

Appendix B Setting Up the Syringe with the Syringe Pump

Setting Up the Syringe Pump

Provides steps for setting up the syringe pump for sample infusion.

Appendix C Divert/Inject Valve

Appendix D Setting Up Sample Introduction Techniques

Setting Up H-ESI or Low Flow H-ESI Direct Infusion

Guides on setting up H-ESI and low-flow H-ESI direct infusion.

Setting Up High-Flow Infusion Without an Autosampler

Explains high-flow infusion using an LC Tee union and syringe pump.

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