Thermo Scientific TSQ Altis User Manual

TSQ Series II
TSQ Altis, TSQ Quantis,
and TSQ Fortis
Hardware Manual
80111-97047 Revision A June 2018

Thermo Scientific TSQ Altis Specifications

General

Brand	Thermo Scientific
Model	TSQ Altis
Category	Laboratory Equipment
Language	English

Summary

Introduction to TSQ Mass Spectrometers

Mass Spectrometry Models

Details the different TSQ mass spectrometer models: Altis, Quantis, and Fortis.

Principles of Operation for TSQ Mass Spectrometers

Overview of the MS System

Provides a block diagram and functional overview of the MS hardware components.

Overview of Ion Optics and Mass Analyzer

Explains how ion optic and mass analyzer assemblies control ion paths from source to detector.

TSQ Vacuum System

Vacuum Pumps

Describes the forepump and turbomolecular pump functions in the vacuum system.

Using the MS Power Options

Shutting Down the MS System in an Emergency

Emergency shutdown procedure for the mass spectrometer system.

Shutting the MS System Down Completely

Shutting the MS Down Completely

Procedure for completely shutting down the mass spectrometer for extended periods.

Restarting the MS System After a Shutdown

Resetting the Mass Spectrometer

Procedure to reset the MS using the communications panel reset button.

Resetting Calibration Parameters

Information on resetting calibration parameters to factory default values.

Maintaining the MS on a Daily Basis

Finding and Fixing Air Leaks

Procedure for identifying and resolving air leaks in the MS system.

Checking the Vacuum Pressure Levels

How to check vacuum pressure readings in the MS for proper operation.

Checking the Argon and Nitrogen Gas Supplies

Guidance on checking argon and nitrogen gas supply levels and pressures.

Flushing the Inlet Components

Procedure for flushing the syringe and inlet components.

Calibrating the MS

Preparing the Syringe Pump for Calibration

Steps to prepare the syringe pump for infusing calibration solution.

Preparing the MS for Calibration

Procedure for preparing the mass spectrometer for calibration.

Evaluating the Spray Stability

Using the Plot Chromatogram tool to evaluate the stability of the spray.

Calibrating and Tuning the MS

Procedure for successful calibration and tuning of the mass spectrometer.

Optimizing the Compound Signal

Optimizing Parameters in the Optimization Pane

Steps to optimize MS parameters within the Optimization pane.

Scan Types

Selected Reaction Monitoring Scan Type

Describes SRM scan for analyzing trace components and monitoring specific transitions.

Acquiring Sample Data

Using Tune to Acquire Sample Data

Step-by-step guide for acquiring sample data using the Tune application.

Using the Xcalibur Data System to Acquire Sample Data

Procedure for acquiring sample data using the Xcalibur data system.

Maintenance Schedule and Supplies

Maintenance Schedule

Details maintenance procedures and their recommended frequencies for MS components.

Maintaining the RF Lens, Exit Lens, MP00 RF Lens, and Lens L0

Removing the API Source Interface

Steps to remove the API source interface for lens maintenance.

Cleaning the RF Lens, Exit Lens, MP00, and Lens L0

Procedure for cleaning the RF lens, exit lens, MP00, and lens L0.

Maintaining the API Source Interface

Removing the Ion Sweep Cone and the Ion Transfer Tube

Procedure for removing the ion sweep cone and ion transfer tube.

Cleaning the Ion Transfer Tube

Procedure for cleaning the ion transfer tube.

Setting Up the Syringe with the Syringe Pump

Setting Up the Syringe Pump

Steps for setting up the syringe pump to infuse samples or load into valves.

Setting Up Sample Introduction Techniques

Setting Up H-ESI or Low Flow H-ESI Direct Infusion

Procedure for infusing samples using H-ESI or low-flow H-ESI direct infusion.

Setting Up High-Flow Infusion Without an Autosampler

Method for high-flow infusion using an LC Tee union and syringe pump.

Setting Up Loop Injections for Flow-Injection Analysis

Technique for manual loop injections with or without an LC column.