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Thermo Scientific TSQ Endura User Manual

Thermo Scientific TSQ Endura
114 pages
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TSQ Series
TSQ Endura and
TSQ Quantiva
Hardware Manual
80100-97014 Revision C February 2017

Table of Contents

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Thermo Scientific TSQ Endura Specifications

General IconGeneral
Mass Analyzer TypeTriple Quadrupole
PolarityPositive and negative
Mass Rangem/z 10 - 3000
Ion SourceAPCI
Dynamic Range6 orders of magnitude
Data AcquisitionSelected Reaction Monitoring (SRM), Full Scan, Product Ion Scan, Precursor Ion Scan, Neutral Loss Scan
Resolution0.7 Da FWHM at unit mass resolution
Polarity Switching Speed20 ms
Operating Temperature15 to 30 °C
Operating Humidity20 - 80% relative humidity, non-condensing

Summary

Regulatory Compliance

Low Voltage Directive 2006/95/EC

Compliance with Low Voltage Directive 2006/95/EC and harmonized safety standard.

EMC Directive 2004/108/EC

Compliance with EMC Directive 2004/108/EC and various EMC standards.

FCC Compliance Statement

Statement of compliance with Part 15 of the FCC Rules.

Chapter 1 Introduction

Mass Spectrometer Models

Details the TSQ Endura and TSQ Quantiva mass spectrometer models and their configurations.

Overview of an LC/MS Analysis

Explains the process of liquid chromatography coupled with mass spectrometry analysis.

Controls and Indicators

Details the front panel controls, buttons, and LED indicators on the mass spectrometer.

Chapter 2 Scan Parameters

Scan Types

Describes various scan types like Full Scan, SIM, Product Ion, Precursor Ion, etc.

Scan Mass-To-Charge Ratio Ranges

Specifies the operating mass-to-charge ratio ranges for TSQ Endura and TSQ Quantiva.

Chapter 3 Vacuum System

Inlet Gases Hardware

Describes the hardware that controls the flow of gases into the mass spectrometer.

Vacuum Manifold

Details the vacuum manifold, its components, and the five vacuum regions.

Vacuum Gauges

Explains the three types of vacuum gauges used to measure pressure in the vacuum manifold.

Vacuum Pumps

Describes the external forepumps and internal turbomolecular pump for vacuum generation.

Atmospheric Pressure Ionization Source

Details the API source, its function as a sample interface, and ionization techniques.

Chapter 4 Ion Transmission and Mass Analysis

Ion Optics

Describes the ion optics elements that focus and transmit gas-phase sample ions.

Mass Analyzers

Details the quadrupole rod assemblies, applied voltages, and mass analysis process.

Dual-Mode, Discrete-Dynode Ion Detection System

Explains the high-sensitivity ion detection system and its detection modes.

Chapter 5 Syringe Pump and Divert/Inject Valve

Chapter 6 System Shutdown, Startup, and Reset

Shutting Down the System in an Emergency

Procedure for immediately powering off the mass spectrometer in an emergency situation.

Shutting Down the Mass Spectrometer Completely

Procedure for completely powering down the system for extended periods or maintenance.

Chapter 7 Daily Operation

Chapter 8 Maintenance

Maintenance Schedule

Lists the routine maintenance procedures and their recommended frequencies.

Chapter 9 Diagnostics and PCB and Assembly Replacement

Running the System Diagnostics

How to run system diagnostics to test major electronic circuits and identify issues.

Chapter 10 Replaceable Parts

API Source Interface

Lists part numbers for TSQ Endura and TSQ Quantiva API source interface components.

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