Name: Waters Synapt HDMS
Brand: Waters
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Waters Vion IMS QTof

Overview and Maintenance Guide

715005046

Version 03

General Information2
Trademarks2
Customer Comments3
Contacting Waters3
Safety Considerations4
Considerations Specific to the Device4
Electrical Power Safety Notice7
Safety Hazard Symbol Notice7
Equipment Misuse Notice7
Safety Advisories8
Operating the Device8
Applicable Symbols8
Intended Use of the Vion IMS Qtof9
Calibrating9
Quality Control10
EMC Considerations10
FCC Radiation Emissions Notice10
Canada Spectrum Management Emissions Notice10
ISM Classification: ISM Group 1 Class a10
Table of Contents11
Waters Vion IMS Qtof Overview17
Waters Vion IMS Qtof17
Automated Setup and Calibration Check17
ACQUITY Vion IMS Qtof UPLC/MS Systems18
Software and Data System19
Lockspray Source and Ionization Modes20
Electrospray Ionization (ESI)21
Atmospheric Pressure Chemical Ionization (APCI)21
Nanolockspray Source and Ionization Modes22
Apgc23
Fluidics System23
Physical Layout of the Fluidics System24
System Operation25
Ion Optics25
Leak Sensors27
Vacuum System27
Preparing the Mass Spectrometer for Operation29
Starting the Mass Spectrometer29
Verifying the Instrument's State of Readiness30
Automated Setup31
Flow Rates for the Vion IMS Qtof System31
Preparing the Fluidics System31
Installing the Reservoir Bottles32
Installing the Low-Volume Vials33
Purging the Fluidics33
Rebooting the Mass Spectrometer33
Leaving the Mass Spectrometer in Standby Mode34
Emergency Shutdown35
Configuring the Lockspray Source36
Configuring for ESI Mode36
Installing the ESI Probe36
Removing the ESI Probe40
Configuring for APCI Mode40
Installing the Ionsabre II Probe41
Removing the Ionsabre II Probe43
Configuring the Nanolockspray Source44
Overview of the Nanolockspray Source44
Sample Sprayer46
Lockspray Sprayer46
Nanoflow Gas Supply46
Purge Gas46
Sprayer Platform Adjuster Assembly46
Selecting and Configuring the Nanolockspray Source47
Deploying the Sprayer Platform Adjuster Assembly47
Moving the Sprayer Platform out of the Source47
Moving the Sprayer Platform into the Source48
Setting up the Camera48
Adjusting the Sprayer Tip Position49
Optional Glass Capillary Sprayer50
Maintenance Procedures51
Maintenance Schedule51
Spare Parts52
Safety and Handling52
Preparing the Instrument for Working on the Source53
Using UNIFI Software to Prepare the Instrument for Working on the Source54
Removing and Refitting the Source Enclosure54
Removing the Source Enclosure from the Instrument54
Fitting the Source Enclosure to the Instrument56
Installing and Removing the Corona Pin57
Installing the Corona Pin in the Source57
Removing the Corona Pin from the Source59
Operating the Source Isolation Valve60
Closing the Source Isolation Valve61
Opening the Source Isolation Valve62
Removing O-Rings and Seals62
O-Ring Removal Kit62
Cleaning the Instrument Case63
Emptying the Nitrogen Exhaust Trap Bottle63
Maintaining the Roughing Pump65
Cleaning the Source Components65
Cleaning the Sampling Cone Assembly66
Removing the Sampling Cone Assembly from the Source66
Disassembling the Sampling Cone Assembly67
Cleaning the Sample Cone and Cone Gas Nozzle69
Assembling the Sampling Cone Assembly71
Fitting the Sampling Cone Assembly to the Source72
Cleaning the Ion Block Assembly73
Removing the Ion Block Assembly from the Source Assembly73
Disassembling the Source Ion Block Assembly74
Cleaning the Ion Block Components79
Assembling the Source Ion Block Assembly80
Fitting the Ion Block Assembly to the Source Assembly81
Cleaning the Stepwave Ion Guide Assembly82
Handling the Stepwave Ion Guide Assembly82
Removing the Ion Block Support from the Source Assembly82
Removing the Stepwave Assembly from the Source Assembly83
Cleaning the Stepwave Ion Guide Assembly85
Fitting the Stepwave Assembly to the Source Assembly87
Fitting the Ion Block Support to the Source89
Maintaining the ESI Probe90
Replacing the ESI Probe Tip and Gasket90
Replacing the ESI Probe Capillary93
Maintaining the Ionsabre II Probe111
Cleaning the Ionsabre II Probe Tip111
Replacing the Ionsabre II Probe Sample Capillary111
Cleaning or Replacing the Corona Pin117
Replacing the Lockspray Reference Probe Capillary118
Removing the Existing Capillary118
Installing the New Capillary120
Replacing the Lockspray II Reference Probe123
Removing the Existing One-Piece Reference Probe125
Installing the New Reference Probe129
Replacing the Nanolockspray Reference Probe Tapertip Emitter or Capillary133
Removing the Nanolockspray Reference Probe133
Installing the New Tapertip Emitter and Capillary135
Replacing the Ionsabre II Probe Heater137
Removing the Ionsabre II Probe Heater137
Fitting the New Ionsabre II Probe Heater139
Replacing the Ion Block Source Heater140
Replacing the Lockspray Source's Assembly Seals143
Removing the Probe Adjuster Assembly Probe and Source Enclosure Seals144
Fitting the New Source Enclosure and Probe Adjuster Assembly Probe Seals145
Replacing the Fluidics Tubing147
Replacing Fluidics Tubing (Standard Configuration)147
Removing the Fluidics Tubing148
Plumbing the Fluidics Lockspray System149
Plumbing the Fluidics Sample Delivery System155
Plumbing the Fluidics Sample Delivery System for Nanolockspray Operation161
Replacing the Instrument's Fuses167
A Safety Advisories169
Warning Symbols169
Notices170
Bottles Prohibited Symbol170
Required Protection171
Warnings that Apply to All Waters Instruments and Devices171
Warnings that Address the Replacement of Fuses175
Electrical Symbols176
Handling Symbols177
B External Connections179
Mass Spectrometer: External Wiring and Vacuum Connections179
Connecting the Ebara Oil-Free Roughing Pump181
Connecting to the Nitrogen Gas Supply185
Connecting to the Collision Cell Gas Supply186
Connecting the Nitrogen Exhaust Line186
Connecting Liquid Waste Lines188
Connecting the Workstation (Systems with no ACQUITY LC)190
Connecting to the Workstation190
Connecting the Workstation to the Power Source191
Connecting Ethernet Cables (Systems with ACQUITY LC)191
Input/Output Signal Connectors192
Signal Connections194
Connecting the Contact-Closure Cable to an ACQUITY LC196
Connecting to the Electricity Source198
C Materials of Construction and Compatible Solvents199
Preventing Contamination199
Items Exposed to Solvent199
Solvents Used to Prepare Mobile Phases200

Brand	Waters
Model	Synapt HDMS
Category	Laboratory Equipment
Language	English

Waters Synapt HDMS Overview And Maintenance Guide

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