Flush the storage solution from the Cadence ILC module following these steps:
1. Direct permeate and retentate lines to drain.
2. Fully open the feed, retentate, and permeate 2 lines, and close the permeate 1 line.
3. Start the feed pump and slowly increase the pump speed until the feed pressure reaches
1.4 – 2.8 barg (20 – 40 psig).
4. Open the permeate 1 line for 1 minute to ensure that the lines are flooded and then close.
5. Subsequently, every 5 minutes, open the permeate 1 line for 30 seconds.
6. Stop the feed pump once 20 L/m
2
of purified water has passed through the module or when
the pH reaches
≤
7.
HELPFUL INFORMATION!
The effectiveness of this flushing protocol will depend on the
composition and volume of chemicals in the module, and minimum acceptable levels in effluent
at the end of the flush. The user must evaluate and validate the effectiveness of the process with
respect to time, temperature and other operating conditions.
HELPFUL INFORMATION!
It is important to remove entrapped air during flushing. If excessive
air is observed exiting the module, increasing feed pressure (maximum of 4.1 barg or 60 psig)
and flow rates will assist in the air removal method. Slight adjustments to the protocol may be
necessary to optimize this step. However, do not exceed the pressure rating of the tubing used.
u
Procedure C — Sanitize the Cadence ILC Module
Sanitize the Cadence ILC module following these steps:
1. Connect the feed line to a supply of sanitization solution (see Section 5.1) at ambient
temperature.
2. Direct permeate and retentate lines to drain.
3. Fully open the feed, retentate, and permeate 2 lines, and close the permeate 1 line.
4. Start the feed pump and slowly increase the pump speed until the feed pressure reaches
1.4 – 2.8 barg (20 – 40 psig).
5. Open the permeate 1 line for 1 minute, and close for the remainder of the sanitization step.
6. Stop the feed pump after 45 L/m
2
of sanitization solution has passed through the module.
HELPFUL INFORMATION!
The effectiveness of this sanitization protocol conducted in
single-pass mode, to reduce or eliminate bioburden, depends on the nature and level of the
contamination. The user must evaluate and validate the effectiveness of the process with
respect to time, temperature, sanitization agent, and other operating conditions.
u
Procedure D — Flush the Cadence ILC Module with Purified Water
Flush the sanitization solution from the Cadence ILC module with purified water following
these steps:
1. Connect the feed line to a supply of purified water.
2. Direct permeate and retentate lines to drain.
3. Fully open the feed, retentate, and permeate 2 lines, and close the permeate 1 line.
4. Start the feed pump and slowly increase the pump speed until the feed pressure reaches
1.4 – 2.8 barg (20 – 40 psig).
5. Open the permeate 1 line for 1 minute to ensure that the lines are flooded and then close.
6. Subsequently, every 5 minutes, open the permeate 1 line for 30 seconds.
7. Stop the feed pump once 20 L/m
2
of purified water has passed through the module or when
the pH reaches
≤
7.
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