REPLIGEN OPUS 14 - 1 Safety Notices; 2 Introduction; What Is Open Platform User Specified (OPUS); Column Design

UG-OPUS® 5-80R
4
OPUS® 5-80R Pre-packed Chromatography Columns
Safety Notices 1
Please abide by the following movement and handling recommendations according to uncrating
guide based on column internal diameter.
Do not pull or strain the white inlet and outlet ports protruding from the top of the OPUS® column.
Table 1. Removal of OPUS
® Pre-packed Columns from Packaging
• Unless otherwise specified by the end-user, OPUS® pre-packed columns are generally
shipped in 20% Ethanol solution, a recognized bacteriostatic agent. Consult the Certificate
of Analysis (CoA) or Certificate of Quality (CoQ) for confirmation of storage solution
• Follow all local regulations for safe disposal
• For laboratory and manufacturing production use only
• Not for administration to humans
Introduction 2
2.1 What is Open Platform User Specified (OPUS®)?
Open Platform User Specified (OPUS®) Columns are designed to perform chromatography
purification of biological molecules in either GMP or non-GMP applications.
The OPUS® Pre-Packed Column platform offers an alternative to conventional “pack in place” glass
or stainless steel columns and can be reliably packed with virtually any resin from any source. To
accommodate a wide range of biopharmaceutical applications, OPUS® Columns are configurable for
nearly any bed height and industry standard internal diameters.
2.2 Column Design
The OPUS® platform has been designed to meet the requirements of GMP manufacturing in the
pharmaceutical and biopharmaceutical industries for campaign-use and single-use applications.
Column Size Instruction
OPUS® 5 - 14 Columns
•
Use two hands to grab the column and lift it from the box
• For OPUS® 14 columns, one handle is provided on the top cap
with additional hand holds on the bottom cap
OPUS® 20 – 30 Columns
• Use two people to grab one handle each
• Lift the column slowly up from the box
• Place it carefully onto the floor or cart. LIFT BY THE HANDLES
ONLY
OPUS® 45R – 60R Columns
• Roll out the column from the wooden crate with the help of
attached casters and ramp
OPUS® 80R Columns
• Roll out the column from the wooden crate with the help of
attached casters and ramp
• Two or more individuals are required to roll the column out
from the crate and about the facility