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UniFlux 30
cytiva UniFlux 30 User Manual
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UniF
lux
30
and
Uni
Flux
1
20
Oper
atin
g
Inst
ruct
ions
Orig
inal
inst
ruct
ions
30
120
cyti
va.c
om
2
Table of Contents
Table of Contents
2
Introduction
5
About this Manual
6
Important User Information
7
Associated Documentation
9
Abbreviations
11
Safety Instructions
12
Safety Precautions
13
Labels
25
Emergency Procedures
29
System Description
33
Configurations
34
Illustrations
35
Standard Components
39
Structural Components
40
Control System Components
42
Connections and Drains
43
Feed Pump and Feed Line
45
Retentate Line
48
Permeate Line
49
Air Integrity Test Device
51
Optional Components
52
Computer and User Console
53
Peristaltic Pumps
54
Multiple Inlets
55
UV Monitor
56
Ph Sensor
57
Conductivity Sensor
58
Feed Tank
59
Filter Dummies
60
Hose Kit
61
Filter Cassette Configuration
62
Filter Cassette Components
63
Cassette Holder
65
Filter Cassettes
67
Hollow Fiber (HF) Configuration
68
Uniflux 30 HF Configuration
69
Uniflux 120 HF Configuration
73
HF Cartridges
77
Meters and Sensors
79
Pressure
80
Flow
81
Ph, Conductivity and UV
82
Temperature
83
More Information
84
Flowcharts
85
External Connections
86
Flow Diagrams
88
UNICORN Control System
93
Installation
97
Site Requirements
98
Transport
100
Unpacking
101
Uniflux Setup
103
Lock the Wheels
104
Operator Console
105
Stand-Alone Computer
109
Setup of Control System and Network
110
Connect Compressed Air Supply
111
Filter Setup, Feed Pump and CFF Filter Protection
113
Process Component Connections
114
Power Supply
117
Operation
121
Prepare the System
123
Sample Handling
124
Start the System and Software
127
Install Hollow Fiber Cartridges
129
Install Filter Cassettes
130
Priming and Testing
136
Calibrations
140
Preparing Mass Measuring
141
Establishing and Entering Holdup Volume
142
Meter Range and Calibration
143
Perform a Run
144
Procedures after Usage
147
Maintenance
148
User Maintenance Schedule
150
Cleaning
152
Important Considerations for Cleaning
154
Cleaning-In-Place (CIP)
156
Storage
158
Disassembly and Assembly
161
Ph Calibration
163
Repair and Calibration
165
Change Filter Type
167
Troubleshooting
171
Reference Information
178
Specifications
179
Signals
184
Battery Limits
186
Chemical Resistance
188
Recycling Information
190
Regulatory Information
191
Contact Information
192
European Union and European Economic Area
193
Eurasian Economic Union
194
Евразийский Экономический Союз
194
Regulations for North America
196
Regulatory Statements
197
Declaration of Hazardous Substances (Dohs)
198
Other Regulations and Standards
200
Further Information
201
Health and Safety Declaration Form
202
A Appendix A: Create a Method with UNICORN 5
204
The Method Editor
205
Introduction to the Method Editor
206
Method Editor Layout
208
Other Method Editor Features
210
An Example of Using the Method Editor
211
Introduction
212
Create the Method
214
Block 1: Initial Conditions
217
Block 2: Product Transfer
220
Block 3: Fed-Batch Concentration
226
Saving the Method
236
Appendix B: Evaluation for UNICORN 5
237
Appendix C: Create a Method with UNICORN 6 and above
240
The Method Editor
241
Introduction to the Method Editor
242
Method Editor Layout
244
Other Method Editor Features
246
An Example of Using the Method Editor
247
Introduction
248
Create the Method
250
Phase 1: Method Settings
252
Phase 2: Product Transfer
256
Phase 3: Fed Batch Concentration
262
Saving the Method
273
Appendix D: PID Control and Feedback Tuning
274
Introduction
275
Using PID Control
277
More Information
278
Index
280
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cytiva UniFlux 30 Specifications
General
Applications
diafiltration
Flow Rate
Up to 30 L/min
Column Size
Not applicable
Connectivity
Ethernet
Temperature Range
4 to 40°C
pH Range
2
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