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T Series
Pall T Series User Manual
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2. Use
scissors
to cut
below the
seal
of the
outer bag.
Do
not to
cut the
inner
bag seal.
Figure 6
Opening Outer Bag
3. Remove
cassette
(still in
the inner
bag) from
the outer
bag.
Figure 7
Cassette Package in Inner Bag
4. T
ur
n the
cassette
so that
the seal
is
turned
upright. Use
scissors to
cut
the
seal of
the inner
bag while
holding
the cassette
upright.
Figure 8
Opening Inner Bag
12
11
13
Table of Contents
Table of Contents
2
Safety Notice
4
Learn Bout Safety
5
Important - Read First
5
Safety Conventions in this Manual
6
Introduction
6
Pplications in TFF
6
Tangential Flow Filtration Process
6
The TFF Process
7
System Hardware Configurations
8
Options
8
System Design
9
Ports and Flow Rate
9
T-Series Cassettes with Omega Membrane Installation
9
First-Time Use of Cassette Holder/Tff System
9
Flush and Clean the System
9
Making a Flushing Gasket
10
System Flushing Protocol
10
Installing T-Series Membrane Cassettes with Omega Membrane into Utotorque ( T) and Manual Torque (MT) Holders
11
Preparation for Loading Cassettes
11
Unpacking the Cassettes
11
Installing Cassettes and Gaskets
13
How to Torque Pall T and MT Cassette Holders
14
Operating Specifications
17
Recommended Cross Flow Rates for T-Series Cassettes with Omega Membrane
17
Operating Pressures, Temperatures and Ph
18
Hold-Up Volume and Minimum Working Volume
18
Determining Feed/Retentate Hold-Up Volume
18
Determining Permeate Hold-Up Volume
19
Determining the Non-Recoverable Volume
20
Determining the System Minimum Working Volume
20
Preconditioning T-Series Cassettes and Systems
21
Using a Cassette for the First Time
22
Initial Flushing of the Cassette and Ssembly (WFI Flush)
22
Flush the Feed/Retentate and Permeate Line to Waste
22
Sanitizing and Depyrogenating the Cassette and Ssembly
23
DD and Recirculate Sanitizing Solution
24
Flushing the Cassette and Ssembly after Sanitization
24
Flush the Retentate and Permeate Line to Waste
25
Water Recirculation
25
Flush the Retentate and Permeate Line to Drain
26
Determine Normalized Water Permeability (NWP20 °C) for Cassettes
27
Remove Ir from Cassette and System
28
Determine Initial Water Permeability (Dead-End Method)
28
Normalize the Water Permeability
30
Example of How to Determine Membrane Water Permeability
30
System and Membrane Cassette Integrity Test
31
Drain the System (Feed/Retentate Flow Path)
32
System Integrity Test (External Test)
33
Membrane Cassette Integrity Test
33
Troubleshooting System Integrity Failure
34
Troubleshooting Membrane Integrity Failure
34
Integrity Testing Systems with Multiple Cassettes
34
Buffer Conditioning
35
Flush the Retentate and Permeate Lines with Buffer
35
Remove Trapped Ir from the Retentate Line
36
Post-Use Treatment of Cassettes and System
37
Flushing Cassettes after Use
37
Flush the Feed/Retentate Line to Waste
37
Flush the Permeate Line to Waste
38
Cleaning Cassettes
38
Dding Cleaning Gent to System
38
Recirculate Cleaning Solution
39
Flush Cleaning Gent from Cassettes and Ssembly
39
Flush the Retentate Line to Waste
40
Flush the Permeate Line to Waste
40
Recirculation Procedure to Reduce Ph, TOC, and Extractables (Optional)
40
Determine Membrane Recovery for the Cassettes
41
Remove Ir from Cassette and System
42
Determine the Water Permeability after Cleaning
42
Normalize the Water Permeability
44
Determine the Membrane Recovery
44
Evaluate the Effectiveness of the Cleaning Regimen
44
Post-Use Ir Integrity Test (Optional)
44
Storage of Membrane Cassettes
45
Recommended Storage Gents for Omega Membranes
45
Dding Storage Gent to System
45
Recirculate Storage Solution
46
Cassette Storage
46
Ppendix
47
Omega Membrane Chemical Compatibility Chart
47
Lternative Cleaning Gents
48
Glossary
49
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Pall T Series Specifications
General
Brand
Pall
Model
T Series
Category
Laboratory Equipment
Language
English
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