Pall T Series User Manual

24
4.3.1 Add and Recirculate Sanitizing Solution
Figure 16
Set-up For Circulating Sanitizing Fluid
Procedure
1. Drain the system and feed tank.
2. Direct the retentate and permeate lines into the feed tank.
3. Fill the feed tank with sanitizing solution.
4. Open the retentate valve. Allow 0.14 barg (2 psig) backpressure. Permeate valve
should be completely open.
5. Adjust the pump to deliver a flow rate of 5 to 10 L/min/m
2
(0.5 to 1 L/min/ft
2
).
Do not exceed a feed pressure of 2.8 barg (40 psig).
6. Adjust the retentate valve to split flow 25% retentate, 75% permeate.
7. Readjust the pump to give required retentate flow rate.
8. Run for 30 minutes.
The effectiveness of this sanitization procedure to reduce or eliminate bioburden will
depend on the nature and level of the contamination. The user must evaluate and
validate the effectiveness of the process with respect to time and temperature and
the effectiveness of the sanitizing agent for their process.
4.4 Flushing the Cassette and Assembly after Sanitization
Water Quality:
WFI at 25 °C or
0.2 µm filtered DI water at 25 °C
Volume Required:
30 L/m
2
(3 L/ft
2
) minimum
Retentate
Permeate
Feed
Tank
Feed
Pump
Rp
Pp
Fp

Pall T Series Specifications

General

Brand	Pall
Model	T Series
Category	Laboratory Equipment
Language	English