Pall T Series User Manual

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Non-Recoverable Volume
The volume remaining in the Feed/Retentate flow path after the flow channel has been pumped
out/drained. Optimization of the product recovery step will insure high product recovery.
Normalized Water Permeability (NWP)
The water flux measured at 20 °C, divided by the average applied transmembrane pressure (TMP).
NVR
Non-volatile residue
NWP Recovery
The percent ratio of the NWP after cleaning relative to the initial NWP measured before the membrane
came into contact with a process fluid.
Permeate (Filtrate)
The portion of sample (feed solution) that has passed through the membrane.
Permeate Flow Rate (Filtrate Flow Rate)
The rate of sample flow through the membrane (rate of sample filtration), measured in volume/unit time.
Permeate Flux (Filtrate Flux Rate)
The rate of sample flow through a given membrane area per unit time. Commonly expressed as LMH
(liters/m
2
/hr).
Permeate Hold-up Volume
The total volume contained within the permeate flow path.
Pyrogen (Endotoxin)
A substance that produces a fever within a warm-blooded animal when injected into the bloodstream.
Retentate
The liquid that flows through the feed/retentate channels of the cassette, returning from the cassette
(retentate port) back to the feed tank.
sccm
Standard Cubic Centimeters per Minute
SIP
Steam in Place. Process where steam sterilization is used in a complete assembled system.
Screen Channel
A tangential flow filtration cassette that contains a screen in the feed/retentate channel. The screen
generates resistance to flow (P) and a gentle turbulence at the membrane surface to minimize the
effects of concentration polarization.
System Hold-up
The total volume contained within the feed/retentate flow path. (Most of this volume is recoverable.)
Tangential Flow Filtration (TFF) (Cross Flow Filtration)
A process which uses a pump to circulate sample across the surface of membranes (“tangential” to the
membrane surface) housed in a multilevel structure (cassette). The applied transmembrane pressure
acts as the driving force to transport solute and small molecules through the membrane. The cross flow
of liquid over the membrane surface sweeps retaining molecules from the surface, keeping them in the
circulation stream.
TCF
Temperature Correction Factors (for Normalizing Water Permeability)
NWP 20 °C = X TCF 20 °C
Permeate Flux Rate (LMH)
TMP
NWP Recovery = x 100%
NWP
after cleaning
NWP initial

Pall T Series Specifications

General

Brand	Pall
Model	T Series
Category	Laboratory Equipment
Language	English