Introduction Page: 3 Notes Cautions and Warnings Highlights important and critical instructions, including notes, cautions, and warnings for safe operation and equipment care.
Regulatory Compliance Details safety standards and compliance with directives such as EMC and Low Voltage directives for the instrument.
Safety Covers essential safety information, including electrical safety and precautions for lifting the instrument.
Electrical Safety Provides crucial guidelines for safe electrical handling and maintenance of the instrument to prevent hazards.
Chapter 1 Introducing the Nano ITC Page: 9 Overview Explains the fundamental principles and methods of calorimeter design and the ITC's differential power compensation approach.
Applications Details the primary application of the Nano ITC, which is batch/incremental titration, explaining its process.
Titration Data Analysis Explains how titration calorimetric experiments yield heat data and the methods for analyzing thermograms and corrections.
Measuring Unit Details the measuring unit, including the calorimeter block, reaction vessels, and access tubes for sample and reference cells.
Reaction Vessel Describes the reaction vessels, including material options and access through platinum tubes for sample and reference cells.
Syringe Stirrer Explains the syringe/stirrer mechanism, including syringe capacities, needle function, and stirring control for optimal efficiency.
Buret Assembly Covers the buret assembly's function in delivering titrant accurately and acting as the stirring mechanism for reactants.
Options and Accessories Lists complementary accessories available for the Nano ITC instrument, such as a degassing station.
Instrument Specifications Provides a detailed table of technical specifications for the Nano ITC instrument, including dimensions, power, and performance parameters.
Chapter 2 Installing the Nano ITC Page: 17 Installing the Instrument Outlines the procedures for installing the instrument, including inspection, connection to the controller, and USB cables.
Inspecting the System Guides users on checking the instrument and shipping container for damage and verifying received parts.
Choosing a Location Offers guidelines for selecting an appropriate location for the Nano ITC, considering environmental conditions and proximity to utilities.
Power Requirements Specifies the power source requirements, including voltage, frequency, and recommendations for surge protection.
Setting Up the Nano ITC Provides basic steps for setting up the Nano ITC, including unpacking, placement, and power connection.
Starting the Nano ITC Explains the steps to power on the instrument and computer system and launch the ITCRun software.
Chapter 3 Use Maintenance & Diagnostics Page: 23 Overview Summarizes the typical steps involved in a Nano ITC experiment, from solution preparation to analysis and cleaning.
Calibrating Chemicals Details chemical calibration methods, focusing on the protonation of Tris base to verify calibration factors.
Sample Preparation Explains the critical importance of degassing water and preparing solutions, including Tris base and HCl, for experiments.
Experiment Setup Covers setting up experiments, including parameters like syringe size, equilibration time, and injection details.
Loading the Buret Details the process of filling the syringe with titrant and loading it into the buret assembly, including handling air gaps.
Starting the Experiment Guides on initiating an experiment, including setting stirrer speed, equilibrating, configuring parameters, and starting the run.
Cleaning the Nano ITC Provides essential procedures for cleaning the sample cells using a cleaning adapter and various solutions for meaningful data.
Analyzing the Data Introduces the software programs ITCRun and NanoAnalyze for data acquisition, analysis, graphing, and export.
Maintaining the Nano ITC Covers essential maintenance tasks for the Nano ITC, including purging the instrument for stable operation.
Troubleshooting the Nano ITC Offers solutions for common issues, including minimizing blank corrections, operating at non-ambient temperatures, and optimizing stirring speeds.
Stable Instrument Operation Provides guidelines and typical values for monitoring instrument behavior to recognize and address abnormal conditions.
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