42 Agilent 6400 Series Triple Quad LC/MS Concepts Guide
3 Agilent Triple Quadrupole MS and Sensitivity
Noise reduction
How the Agilent 6400 Series Triple Quadrupole instrument
minimizes noise
1 Agilent’s orthogonal spray sources maximize ionization while
minimizing solvent and matrix noise.
2 This combination of a heated counter-current drying gas,
dielectric capillary and skimmer enhances desolvation while
minimizing chemical noise.
3 RF Octopole ion guide provides high efficiency ion capture
while optimizing wide mass bandwidth ion transmission.
4 L2 RF enhances high mass ion transmission.
5 Quadrupole 1 uses hyperbolic quadrupoles to optimize ion
transmission and spectral resolution.
6 RF quadrupole segment enhances ion transmission into and
out of the collision cell.
Crosstalk is the interference
caused when two signals
become partially superimposed
on each other. In this case residual
product ions can interfere with the
product ion spectrum of a
subsequent MRM experiment.
7 High pressure collision cell with linear acceleration
optimizes MS/MS fragmentation while eliminating crosstalk,
even at very low dwell times. A small diameter high
frequency hexapole assembly assists with capturing and
focusing fragmented ions. For the 6490, the hexapole field
axial focusing curved collision cell includes a tapered cell
structure for increased ion acceptance at the entrance. Its
structure reduces the ionizer generated noise.
8 Quadrupole 2 uses hyperbolic quadrupoles to optimize ion
transmission and spectral resolution.
9 The off-axis matching dual high energy dynode detector with
log amp signal compression permits a high gain with rapid
polarity switching, a long life and low noise. The off-axis
design allows neutrals to pass without hitting the detector.
10 The multiplier has a long life since only electrons impact its
surface, never ions.
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