Inner Workings – Triple Quadrupole MS versus Single Quadrupole MS 2
Innovative Enhancements in the 6490 Triple Quadrupole
Agilent 6400 Series Triple Quad LC/MS Concepts Guide 23
Figure 8 Innovative Enhancements in the 6490
The quadrupole consists of four parallel hyperbolic rods
through which selected ions are filtered before reaching
a collision cell where they are fragmented. The collision cell is
typically called the second quadrupole, but in the case of the
6460, geometrically it is actually a hexapole filled with nitrogen,
the same gas used in the ion source. In the 6490, the collision
cell is a hexapole field axial focusing curved collision cell.
The fragment ions formed in the collision cell are then sent to
the third quadrupole for a second filtering stage to enable
a user to isolate and examine multiple precursor to product ion
transitions (MRMs).
Innovative Enhancements in the 6490 Triple Quadrupole
The iFunnel Technology encompasses the first three
enhancements to the 6490: a hexabore capillary, the Dual Ion
Funnel technology and the Curved Collision Cell. The fourth
enhancement is improved quadrupole drive electronics.
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