8 Agilent 6400 Series Triple Quad LC/MS Concepts Guide
1Overview
What kind of system do you have?
What kind of system do you have?
You can set up an A gilent 6400 Series Triple Quadrupole LC/MS in
several configurations:
ESI – Electrospray Ionization
APCI – Atmospheric Pressure
Chemical Ionization
APPI - Atmospheric Pressure
Photo Ionization
HPLC-Chip/MS – High Performance
Liquid Chromatography on a Chip
MMI - Multimode Ionization
• For normal flow LC/MS with a binary pump, quaternary pump,
well-plate sampler (or autosampler or CTC PAL autosampler).
The supported ion sources are ESI, APCI, APPI, and MMI.
• For microflow LC/MS with a capillary pump, micro well-plate
sampler (or CTC PAL micro-plate autosampler) and ESI, APCI or
MMI ion sources
• For nanoflow LC/MS with a nanoflow pump, capillary pump,
micro well-plate sampler and HPLC-Chip/MS interface (used
in place of a standard nanospray source) to increase
reliability and boost performance with narrow peak
dispersion and lower dead volumes.
Each Agilent combination has advantages for different
applications. Each uses the same Data Acquisition program,
Quantitative Analysis program and Qualitative Analysis
program to enable these advantages.
The Agilent 6460 and 6490 Triple Quadrupole LC/MS systems
are the only Triple Quadrupole that can use the Agilent Jet
Stream Technology. This technology utilizes a super-heated
sheath gas to collimate the nebulizer spray which dramatically
increases the number of ions that enter the mass spectrometer.
The Agilent 6490 Triple Quadrupole LC/MS system also utilizes
the iFunnel Technology which includes the Agilent Jet Stream
Technology, shorter desolvation assembly with Hexabore
Capillary, and the Dual Offset Ion Funnel.
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