50 Agilent 6400 Series Triple Quad LC/MS Concepts Guide
3 Agilent Triple Quadrupole MS and Sensitivity
LC/MS ion sources
The Agilent 6490 Triple Quadrupole has a Hexabore Capillary
which samples up to 10 times more ion rich gas from the source.
The capillary in the 6460A, the 6430A and the 6420A is a
resistive capillary that improves ion transmission and allows
virtually instantaneous polarity switching. It is the same,
proven capillary that is used in the fast polarity switching
version of Agilent's single quadrupole product.
For the Agilent 6410 Triple Quadrupole, the capillary is glass,
dielectric “cold” capillary that enhances desolvation and
improves the focusing of high mass ions while minimizing
chemical noise. Some desolvation occurs in the capillary. This
appears to work better with glass capillaries rather than
stainless steel capillaries and reduces cluster noise. Ion
focusing is also improved.
Atmospheric Pressure Chemical Ionization (APCI)
Atmospheric Pressure Chemical Ionization (APCI) is a popular
complement to electrospray. Because APCI does not generate
multiply charged ions, and operates at higher temperatures, it is
commonly used to analyze smaller, thermally stable polar and
non-polar compounds. Agilent's APCI source is sensitive, yet
extremely robust thanks to orthogonal spray and counterflow
drying gas. Like the ESI source, it can generate both positive
and negative ions, and ion polarity can be switched on a
spectrum-to-spectrum basis.
Agilent multimode source
The most versatile ion source for the Agilent 6400 Series Triple
Quadrupole MS is Agilent’s G1978B Multimode Source shown
diagrammatically in Figure 24.
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